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As the principal investigator of the Image-Guided Surgery group (Greenlight.nu) I focus on preclinical and clinical studies on intraoperative near-infrared (NIR) fluorescence imaging. The goal of our research is to validate image-guided surgery using clinically available tracers and to clinically translate novel agents in close collaboration with industry or academia (e.g. John Frangioni at Harvard / Curadel, Sam Ghambir, Chair of Radiology at Stanford, Ronan Cahill and Donal O’Shea, in Dublin, James Basilion, Case Western Reserve University, Cleveland).
Clinical translation of promising imaging agents will be obtained by designing clever pre-clinical and clinical studies (knowledge-based approach) to obtain proof of principle and proof of concept. Latter is also part of an ongoing collaboration between the Strategic Fund partners (Department of Radiology (Prof Fijs van Leeuwen), Surgery (Prof Jos van der Hage), CHDR (Prof Koos Burggraaf) and LUMC pharmacy (Martin Pool)) focusing on image-guided healthcare and this will provide a fast-track pipeline of targeted agent development to allow bench to bedside translation using a short cycle strategy (including alignment of available LUMC infrastructure).
To facilitate clinical translation of novel developed probes, my group has a very strong collaboration with the Centre for Human Drug Research (CHDR) and Ph.D. students are appointed both at LUMC and CHDR. Successful clinical translation using the unique resources (including GMP facility (KFT-IGFL) and Division of Image Processing) available at LUMC has already been achieved for five novel fluorescent imaging agents. In addition, we aim at disseminating this technique to collaborating hospitals all over the world. Part of this strategy is initiating several multicenter trials with both academic and non-academic hospitals, for example the Erasmus Medical Center (EMC), Catharina hospital (Eindhoven), Medisch Centrum Haaglanden, Mass General (Boston), UMASS (Boston), Cleveland Clinic (Florida, USA), UCSD (San Diego, USA). Our research contributes to the LUMC research profile areas Cancer and Academic Pharma.
Since 2008 I am the supervisor of 42 Ph.D. students of which 20 have already completed their Ph.D. thesis (listed below) including one defense with honors. Furthermore, 3 post-docs / co-investigators of our team have received either a Bas Mulder award (Alpes d’HuZes) or a KWF young investigator award for further clinical implementation of targeted fluorescence-guided surgery. To strengthen the collaboration with EMC in the field of advanced imaging, we appointed Dr Denise Hilling, who is a fellow oncologic and gastro-intestinal surgery at EMC for one day per week as research leader image-guided surgery and precision medicine at LUMC. Together, we intend to intensify the already ongoing collaboration with professor Kees Verhoef (surgery) in the context of Medical Delta. Up to date, the total number of publications by our group is over 238 (h-index of 44). I was awarded with a clinical cancer research award from the Dutch Cancer Society to implement image-guided surgery in daily clinical practice, and involved in several large research projects, including projects funded by the European Union (H2020, ITEA, and ECSEL framework), National Institute of Health (NIH-RO1), Dutch Cancer Society (personal, regular and consortium grants), Dutch Research Council and in the past the Center for Translational Molecular Imaging (CTMM). To promote valorization of the developed technology at LUMC, I am a founding member and past chairperson of the Study Group “Intra-Operative Imaging” from the European Society of Molecular Imaging (ESMI) and a member of the International Advisory Committee of the International Society for Fluorescence-Guided Surgery (ISFGS) and recently, a founding member of the European Chapter of the ISFGS. As part of my role in ISFGS, I am also a faculty member of the Foregut Meeting (CME courses) organized yearly by The Cleveland Clinics. I am also a member of the program committee and speaker of the yearly organized SPIE Photonics West BiOS conference in San Francisco entitled: Molecular-Guided Surgery: Molecules, Devices, and Applications. BiOS is the world’s largest international biomedical optics conference, encompassing clinical, translational, and fundamental research and development in the field of biomedical optics and photonics.
Over the next 5 years, the type and number of imaging agents as well as imaging devises studied will be increased with the singular goal of improving patient care. As surgical guidance plays a key role to improve patient outcomes, image fusion (including pre-operatively obtained images) combined with AI and AR will further tailor the surgical procedure and may even allow procedure training before the actual surgical treatment.
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SURGERIESno. 1 (2024): 49-62
FRONTIERS IN ONCOLOGY (2023): 1147849-1147849
Cancersno. 5 (2023): 1587-1587
Lukas J.A.C. Hawinkels,Patricia Kuiper,Eliza Wiercinska,Hein W. Verspaget,Zhen Liu,Evangelia Pardali,Cornelis F.M. Sier,Peter ten Dijke
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Biomedicinesno. 3 (2023): 982-982
Bernadette Jeremiasse,Zeger Rijs, Karieshma R Angoelal,Laura S Hiemcke-Jiwa, Ella A de Boed,Peter J K Kuppen,Cornelis F M Sier,Pieter B A A van Driel,Michiel A J van de Sande,Marc H W A Wijnen,Anne C Rios,Alida F W van der Steeg
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