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Bio
Our laboratory studies the assembly and egress of viruses with a focus on the cellular mechanisms utilised and modified by viruses during their replication. We primarily study two families of important human pathogens: herpesviruses and polyomaviruses.
Herpesviruses are large (~200nm) and complex enveloped dsDNA viruses that are ubiquitous pathogens of vertebrates and establish life-long latent infections in their hosts. Infections by the nine known human herpesviruses are associated with many serious diseases including certain lymphomas and life-threatening conditions in immuno-compromised patients. The assembly of herpesviruses is known to involve the budding of nucleocapsids, together with the complex layer of tegument proteins, at membranes derived from post-Golgi endocytic compartments. Once formed, the membrane-bound compartments containing the mature virions undergo exocytosis to release infectious viruses from the cell.
Herpesviruses are large (~200nm) and complex enveloped dsDNA viruses that are ubiquitous pathogens of vertebrates and establish life-long latent infections in their hosts. Infections by the nine known human herpesviruses are associated with many serious diseases including certain lymphomas and life-threatening conditions in immuno-compromised patients. The assembly of herpesviruses is known to involve the budding of nucleocapsids, together with the complex layer of tegument proteins, at membranes derived from post-Golgi endocytic compartments. Once formed, the membrane-bound compartments containing the mature virions undergo exocytosis to release infectious viruses from the cell.
Research Interests
Papers共 72 篇Author StatisticsCo-AuthorSimilar Experts
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Cell Host & Microbeno. 4 (2024): 466-478.e11
Henry T.W. Blest, Alexander Redmond, Jed Avissar, Jake Barker,Anne Bridgeman,Gerissa Fowler,Lise Chauveau,Jonny Hertzog,Iolanda Vendrell,Roman Fischer,Marie B. Iversen,Lichen Jing,
Laura Caller,Sophia Ho, Katherine Brown,Liane Dupont, Tjasa Zalatel,Rupert Beale,Paul J. Lehner,Colin M. Crump
crossref(2023)
The Journal of general virologyno. 4 (2023)
Laura Caller,Sophia Ho, Katherine Brown,Liane Dupont, Tjasa Zalatel,Rupert Beale,Paul J. Lehner,Colin M. Crump
biorxiv(2023)
Journal of virologyno. 1 (2022): e0133122-e0133122
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