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个人简介
Our laboratory studies the assembly and egress of viruses with a focus on the cellular mechanisms utilised and modified by viruses during their replication. We primarily study two families of important human pathogens: herpesviruses and polyomaviruses.
Herpesviruses are large (~200nm) and complex enveloped dsDNA viruses that are ubiquitous pathogens of vertebrates and establish life-long latent infections in their hosts. Infections by the nine known human herpesviruses are associated with many serious diseases including certain lymphomas and life-threatening conditions in immuno-compromised patients. The assembly of herpesviruses is known to involve the budding of nucleocapsids, together with the complex layer of tegument proteins, at membranes derived from post-Golgi endocytic compartments. Once formed, the membrane-bound compartments containing the mature virions undergo exocytosis to release infectious viruses from the cell.
Herpesviruses are large (~200nm) and complex enveloped dsDNA viruses that are ubiquitous pathogens of vertebrates and establish life-long latent infections in their hosts. Infections by the nine known human herpesviruses are associated with many serious diseases including certain lymphomas and life-threatening conditions in immuno-compromised patients. The assembly of herpesviruses is known to involve the budding of nucleocapsids, together with the complex layer of tegument proteins, at membranes derived from post-Golgi endocytic compartments. Once formed, the membrane-bound compartments containing the mature virions undergo exocytosis to release infectious viruses from the cell.
研究兴趣
论文共 71 篇作者统计合作学者相似作者
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Cell Host & Microbe (2024)
Henry T.W. Blest, Alexander Redmond, Jed Avissar, Jake Barker,Anne Bridgeman,Gerissa Fowler,Lise Chauveau,Jonny Hertzog,Iolanda Vendrell,Roman Fischer,Marie B. Iversen,Lichen Jing,
Kamal L Nahas, Vivienne Connor,Kaveesha J Wijesinghe, Henry G Barrow,Ian M Dobbie,Maria Harkiolaki, Stephen C Graham,Colin M Crump
biorxiv(2024)
The Journal of general virologyno. 4 (2023)
Laura Caller,Sophia Ho, Katherine Brown, Liane Dupont, Tjasa Zaletel,Rupert Beale,Paul J Lehner,Colin M Crump
biorxiv(2023)
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Biological imaging (2022)
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