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个人简介
RESEARCH FOCUS
Clint RubinThe major research focus of our lab's work is targeted towards understanding the cellular mechanisms responsible for the growth, healing and homeostasis of bone. More specifically, we are interested in how biophysical stimuli (e.g., mechanical, electrical, ultrasound) mediate these responses. The clinical significance of this work is applicable to the inhibition of osteopenia, the promotion of bony ingrowth into prostheses or skeletal defects and the acceleration of fracture healing. These goals are approached via interdisciplinary studies at the biochemical, molecular, cellular, tissue, organ, computational (e.g., FEM) and clinical levels. Our lab is also very interested in how mechanical signals bias the fate selection of mesenchymal and hematopoietic stem cells, as a means of treating obesity and diabetes through developmental, rather than metabolic pathways.
Dr. Rubin’s research into non-invasive, non-pharmacological intervention to control osteoporosis was referenced in National Geographic’s January 2001 article about surviving space travel. His studies show that the application of extremely low level strains to animals and humans will increase bone formation and thus may represent the much sought after “anabolic” stimulus in bone.
Dr. Rubin is also working in collaboration with Marodyne Medical to bring Low Intensity Vibration to the clinic for non-drug therapies for injury and disease.
Our work on mechanical biasing of stem cells away from fat and towards bone, has inspired cartoonist Nicole Hollander to capture the "translational essence" of the work. The two-panel carton strip titled "Sylvia" was published around the world, on May 5, 2008.
Clint RubinThe major research focus of our lab's work is targeted towards understanding the cellular mechanisms responsible for the growth, healing and homeostasis of bone. More specifically, we are interested in how biophysical stimuli (e.g., mechanical, electrical, ultrasound) mediate these responses. The clinical significance of this work is applicable to the inhibition of osteopenia, the promotion of bony ingrowth into prostheses or skeletal defects and the acceleration of fracture healing. These goals are approached via interdisciplinary studies at the biochemical, molecular, cellular, tissue, organ, computational (e.g., FEM) and clinical levels. Our lab is also very interested in how mechanical signals bias the fate selection of mesenchymal and hematopoietic stem cells, as a means of treating obesity and diabetes through developmental, rather than metabolic pathways.
Dr. Rubin’s research into non-invasive, non-pharmacological intervention to control osteoporosis was referenced in National Geographic’s January 2001 article about surviving space travel. His studies show that the application of extremely low level strains to animals and humans will increase bone formation and thus may represent the much sought after “anabolic” stimulus in bone.
Dr. Rubin is also working in collaboration with Marodyne Medical to bring Low Intensity Vibration to the clinic for non-drug therapies for injury and disease.
Our work on mechanical biasing of stem cells away from fat and towards bone, has inspired cartoonist Nicole Hollander to capture the "translational essence" of the work. The two-panel carton strip titled "Sylvia" was published around the world, on May 5, 2008.
研究兴趣
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Journal of Adolescent Healthno. 3 (2024): S14-S15
Zhengyuan Bao,Can Cui, Chaoran Liu,Yufeng Long, Ronald Man Yeung Wong,Senlin Chai, Ling Qin,Clinton Rubin,Benjamin Hon Kei Yip, Zhihong Xu,Qing Jiang,Simon Kwoon-Ho Chow,
AGING CELLno. 7 (2024): e14156-e14156
M. Ete Chan, Christopher Ashdown,Lia Strait,Sishir Pasumarthy, Abdullah Hassan,Steven Crimarco, Chanpreet Singh,Vihitaben S. Patel,Gabriel Pagnotti, Omor Khan, Gunes Uzer,Clinton T. Rubin
Mechanobiology in Medicineno. 4 (2024): 100080
BMJ OPENno. 1 (2024): e074858-e074858
Journal of Immunologyno. 1 (2023): 68.02-68.02
bioRxiv the preprint server for biology (2023)
Maria Luisa Bianchi,Silvia Vai, Giovanni Baranello,Francesca Broggi,Stefan Judex,Thomas Hangartner,Clinton Rubin
JBMR Plusno. 11 (2022): n/a-n/a
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