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Bio
From an entity perspective, research of the lab is centered around hematological malignancies, but also reaches out to GI tract cancers, melanoma and breast cancer. We have a long-standing interest in cellular failsafe mechanisms, i.e. programmed responses to severe cellular insults, as barriers to tumor manifestation, and, likewise, as effector principles of anticancer therapies. Complementing apoptosis and autophagy, cellular senescence is the failsafe program we are mostly interested in, because this terminal cell-cycle arrest condition has far-reaching ramifications in tumor biology, immunology, and treatment outcome. We investigate molecular mechanisms and translational implications of senescence in mouse models of lymphoma and melanoma, further exploit molecular findings in patient-reminiscent clinical trial-like “panomics” mouse studies, and probe their relevance in cross-species investigations of human tumor material with annotated clinical courses of the patients the material was derived from. More specifically, test platforms for primary patient-derived material include xenografts in mice, lymphoma-on-a-chip and other novel biotechnological approaches and will implment synthetic biology, too. Our interest in senescence spans fundamental cell biology ([epi-]genomics to systems biology), dynamics/reversibility and reprogramming/plasticity (e.g. senescence-associated stemness) over time, as well as host immune interdependencies.
Research Interests
Papers共 198 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
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期刊级别
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合作机构
American journal of hematologyno. 5 (2024): 1008-1011
JOURNAL OF EXPERIMENTAL MEDICINEno. 4 (2024)
Cancer Researchno. 9_Supplement (2024): PO4-04
Cancer Researchno. 9_Supplement (2024): PO1-05
Cancer Researchno. 9_Supplement (2024): PO1-01
Yi Bei,Luca Bramé,Marieluise Kirchner,Raphaela Fritsche-Guenther,Severine Kunz,Animesh Bhattacharya, Mara-Camelia Rusu,Dennis Gürgen, Frank P.B. Dubios, Julia K.C. Köppke,Jutta Proba,Nadine Wittstruck,
crossref(2024)
Yi Bei,Luca Brame,Marieluise Kirchner,Raphaela Fritsche-Guenther,Severine Kunz,Animesh Bhattacharya, Mara-Camelia Rusu,Dennis Guergen, Frank P. B. Dubios, Julia K. C. Koeppke,Jutta Proba,Nadine Wittstruck,
Cancer discoveryno. 3 (2024): 492-507
GTH Congress 2023 – 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research – The patient as a benchmarkHämostaseologie (2023)
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Author Statistics
#Papers: 199
#Citation: 12759
H-Index: 43
G-Index: 112
Sociability: 7
Diversity: 3
Activity: 64
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