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We seek to decipher how organisms confronted with several environmental cues are able to regulate their gene expression in order to maintain proper homeostatic control. Metals are of the most important environmental toxics that cause several diseases. We are studying how gene expression is regulated under conditions of Arsenic stress, Iron and Cobalt overloading. As such we are studying the role of the family of the Yeast activator transcription factors (Yaps) in stress response. We were at the origin of discovering these factors and some of their function. We are also interested in the understanding how stress-responsive genes are activated at the level of transcription. We found that Yap8, an arsenic responsive factor binds the Mediator complex via the Med2 a subunit located in the tail of that complex. Our research investigations use the budding yeast Saccharomyces cerevisiae. We are also investigating NO detoxification in both prokaryotic and eukaryotic microorganims in order to get insights into the evolutionary conservation of the mechanisms involved.
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JBIC Journal of Biological Inorganic Chemistryno. 8 (2020): 1117-1128
Claudina Rodrigues-Pousada,Frédéric Devaux,Soraia M. Caetano,Catarina Pimentel,Sofia da Silva, Ana Carolina Cordeiro,Catarina Amaral
Biochimica et biophysica acta. General subjectsno. 10 (2018): 2152-2161
Biochimica et biophysica acta. Gene regulatory mechanismsno. 4 (2017): 472-481
FEBS JOURNALno. SUPnan (2016): 384-384
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