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Bio
Cláudia Saraiva was granted a PhD in Bioengineering (MIT-Portugal) from the New University of Lisbon. During her thesis, she used microRNA-loaded nanoparticles (miR-NP) as therapeutic agents to promote neuronal differentiation of neural stem cells and consequently ameliorate brain damage in PD and stroke models. Her PhD project provided evidence supporting miR-124 NP as positive modulators of endogenous neurogenesis and their potential application in brain repair strategies (Saraiva et al., J Control Rel, 2016; Saraiva et al, PLOS One, 2018). This work was developed under the supervision of Dr. Liliana Bernardino and co-supervision of Dr. Lino Ferreira, two leading investigators in the fields of neural stem cells and biomaterials, at the Health Science Research Center (CICS), University of Beira Interior, Covilhã, Portugal. Part of the PhD work regarding stroke was developed at the Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University under the supervision of Dr. Karsten Ruscher. Currently, she is a staff scientist at Jens Schwamborn lab where is leading (PI) a project using human Midbrain organoids derived from iPSCs from PD patients to disclose the role of dysfunctional mitochondria in dopaminergic degeneration. Cláudia aims to continually grow her expertise in the stem cell field and contribute to a better understanding of PD pathology as well as in the development of 3D brain models.
Research Interests
Papers共 26 篇Author StatisticsCo-AuthorSimilar Experts
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npj Parkinson's Diseaseno. 1 (2023): 1-16
Molecular neurobiologyno. 8 (2023): 4246-4260
Kyriaki Barmpa,Claudia Saraiva,Gemma Gomez-Giro, Elisa Gabassi,Sarah Spitz,Konstanze Brandauer, Juan E. Rodriguez Gatica,Paul Antony,Graham Robertson,Florentia Papastefanaki,Ulrich Kubitscheck,Ahmad Salti,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Axel Chemla,Giuseppe Arena, Ginevra Sacripanti,Kyriaki Barmpa,Alise Zagare,Pierre Garcia,Paul Antony, Jochen Ohnmacht,Alexandre Baron, Jaqueline Jung,Anne-Marie Marzesco,Manuel Buttini,
biorxiv(2023)
Nature Communicationsno. 1 (2022)
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