基本信息
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Career Trajectory
Bio
Franzini-Armstrong's primary interest in science has been the disposition of membranes and macromolecular complexes that are responsible for excitation-contraction (e-c) coupling in cardiac and skeletal muscles.She engaged in four main phases of structural work in terms of her career. Her first phase focused on calcium cycling and, especially, on defining the distribution and nature of the two membrane systems involved in this specific type of cycling. Franzini-Armstrong's second phase discovered the location of channels that release calcium during muscle activation. She also demonstrated that in muscles that can engage in high activity rates, a limiting factor is the density of the pump protein and not the density of calcium release channels.Furthermore, the third phase of Franzini-Armstrong's structural work recognized the relationship between the L type calcium channels of the plasmalemma and T tubules in cardiac and skeletal muscles. Specifically, she worked with CaV channels or dihydropyridine receptors (DHPRs) and the calcium release channels of the sarcoplasmic reticulum (RyRs).Her fourth phase, which continues to be her current interest, is the supramolecular complex that enables several molecules located in the sarcoplasmic reticulum that regulate calcium release to interact with one another. In her current work, Franzini-Armstrong continues to utilize structural approaches in order to better comprehend the different interactions between molecules.
Research Interests
Papers共 179 篇Author StatisticsCo-AuthorSimilar Experts
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EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGYno. 1 (2024)
Frontiers in Physiology (2022): 1036594-1036594
Proceedings of the National Academy of Sciencesno. 19 (2022)
The New England journal of medicineno. 9 (2020): 835-844
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