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Bio
Charles L. Loprinzi, M.D., is a medical oncologist whose primary research interest for more than 25 years has related to symptom control clinical trials — trials devoted to the treatment, prevention or better understanding of untoward symptoms that are related to cancer, cancer treatment or both.
Dr. Loprinzi has led a group that has conducted well over 100 symptom control trials, most of them placebo-controlled trials. This work has addressed the management of mouth sores or inflammation of the esophagus or bowels (gastrointestinal mucosal toxicity); cancer-related loss of appetite, weight or both (anorexia-cachexia); chemotherapy-induced hot flashes, skin toxicity, sexuality symptoms, numbness, tingling, pain or a combination (chemotherapy-induced neuropathy); arm swelling (lymphedema); cognitive dysfunction; bone thinning (osteoporosis); insomnia; and fatigue. His primary clinical interest is breast cancer, and thus many of the trials he has conducted relate to this area.
Arguably, Dr. Loprinzi has been at the heart of defining more treatment approaches for uncontrolled symptoms in patients with cancer than any other individual over the past three decades.
Focus areas
Chemotherapy-induced peripheral neuropathy. Dr. Loprinzi and his team have led more clinical trials aimed at the prevention or treatment of chemotherapy-induced neuropathy than any other group in the world. Through these efforts, he has been able to delineate the risks and benefits of different treatment approaches for preventing or treating chemotherapy neuropathy. His work has also helped to define the clinical details of chemotherapy neuropathy.
Hot flashes. Hot flashes are a major problem for many women and men who have therapy to deplete testosterone. Dr. Loprinzi's research group has conducted more trials aimed at the treatment of hot flashes in women and men than any other group in the world. He and his group have been able to delineate nonestrogenic treatments that are effective for hot flashes. This includes the use of low doses of antidepressants for treating hot flashes.
Anorexia and cachexia. Appetite loss and weight loss are common in many patients with advanced cancer. Dr. Loprinzi and his group have conducted more clinical trials aimed at treatment of these vexing problems than any other group in the world. Through this work, they have been able to define what works and what does not work for treatment of this clinical situation.
Research Interests
Papers共 725 篇Author StatisticsCo-AuthorSimilar Experts
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Vered Stearns,Opeyemi A Jegede,Victor Tsu-Shih Chang,Todd C Skaar, Jeffrey L Berenberg, Ranveer Nand,Atif Shafqat,Nisha Lassi Jacobs,William Luginbuhl,Paul Gilman,Al B Benson, Judie R Goodman,
Cancer Researchno. 9_Supplement (2024): PO2-13
Ellen M. Lavoie Smith,Youmin Cho,Shauna Hillman, Mary R. Scott, Elizabeth Harlos,Rachel Wills,Charles Loprinzi,Christina M. Wilson,David Zahrieh
JNCI CANCER SPECTRUMno. 1 (2024)
Jessica Frances Burlile, Joshua Cameron, Heather Gunn, Nicole Larson, Judy Caroline Boughey, Mary Megan Mrdutt, Fergus Couch, Janet E. Olson, Jennifer L. Bradt, Yasamin Sharifzadeh, Kathryn Jean Ruddy, Dean Shumway,
Journal of Clinical Oncologyno. 16_suppl (2024): 12048-12048
Cancer Researchno. 9_Supplement (2024): PO5-12
Journal of Thrombosis and Haemostasis (2024): 100293-100293
Miguel Muniz,Charles L Loprinzi,Jacob J Orme, Regina M Koch,Ahmed M Mahmoud,Adam M Kase,Irbaz B Riaz,Jack R Andrews,Matthew P Thorpe,Geoffrey B Johnson,Ayse T Kendi,Eugene D Kwon,
Cancer Treatment Reviews (2024): 102748-102748
Scientific Reportsno. 1 (2024): 1-9
Vered Stearns,Opeyemi A. Jegede,Victor Tsu-Shih. Chang,Todd C. Skaar, Jeffrey L. Berenberg, Ranveer Nand,Atif Shafqat,Nisha Lassi. Jacobs,William Luginbuhl,Paul Gilman,Al B. Benson, Judie R. Goodman,
Clinical Cancer Research (2024)
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