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个人简介
My research is aimed at unraveling the causal genetic factors behind some hereditary diseases. How does variation in hereditary material lead to disease and how can we use such knowledge to prevent or treat diseases? My PhD research focused on a relatively simple genetic disorder that is inherited according to Mendelian laws. In 1995, I was one of the first to take up the challenge of searching for the genetic factors that determine more complex disorders. My group adopted a hypothesis-generating, genome-wide approach, and was able to make great progress on elucidating the genetic factors for celiac disease, intracranial aneurysms, type 2 diabetes and celiac disease. We are now working on systems genetics approaches towards understanding complex diseases and innovative organ-on-chip models for functional testing under specific genetic and tissue backgrounds.
研究兴趣
论文共 877 篇作者统计合作学者相似作者
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Jelle Slager, Hanna L. Simpson,Ranko Gacesa,Lianmin Chen, Jody Gelderloos,Astrid Maatman,Cisca Wijmenga,Alexandra Zhernakova,Jingyuan Fu,Rinse Weersma, Gieneke Gonera,Iris H. Jonkers,
biorxiv(2024)
Sanzhima Garmaeva,Trishla Sinha,Anastasia Gulyaeva, Nataliia Kuzub,Johanne E. Spreckels,Sergio Andreu-Sánchez,Ranko Gacesa, Arnau Vich Vila,Siobhan Brushett, Marloes Kruk, Aafje Dotinga, Jackie Dekens,
Nature Communicationsno. 1 (2024): 1-19
Asier Fernández-Pato,Trishla Sinha,Ranko Gacesa, Sergio Andreu-Sánchez, Milla F. Brandao Gois, Jody Gelderloos-Arends, Dianne B. H. Jansen, Marloes Kruk,Martin Jaeger,Leo A. B. Joosten,Mihai G. Netea,Rinse K. Weersma,
Daria V. Zhernakova,Daoming Wang, Lei Liu,Sergio Andreu-Sánchez,Yue Zhang,Angel J. Ruiz-Moreno, Haoran Peng,Niels Plomp, Ángela Del Castillo-Izquierdo,Ranko Gacesa,Esteban A. Lopera-Maya,Godfrey S. Temba,
Natureno. 7996 (2024): 813-821
EBioMedicine (2024): 104956
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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2023): 19-19
Sanzhima Garmaeva,Trishla Sinha,Anastasia Gulyaeva, Nataliia Kuzub,Johanne E. Spreckels,Sergio Andreu‐Sánchez,Ranko Gaćeša,Arnau Vich Vila,Siobhan Brushett, Marloes Kruk,Jackie Dekens,Jan Sikkema,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Nature Geneticsno. 7 (2023): 1091-1105
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Victoria E J M Palasantzas, Isabel Tamargo-Rubio,Kieu Le,Jelle Slager,Cisca Wijmenga,Iris H Jonkers,Vinod Kumar,Jingyuan Fu,Sebo Withoff
biorxiv(2023)
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