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个人简介
My main research focus is to understand virus infection, pathogenesis and host-virus interactions. I use recombinant viruses to infect different cell lines or animal models to observe viral replication and infection dynamics and host immunological response to the infections. Recombinant viruses are effective tools to discover the possible functions of viral proteins in comparison with wild type viruses. This methodology also serves to observe different immune responses of the cell lines and different pathogenesis on animal models that will also participate potential vaccine candidate discoveries. Previously, I used the model organism Caenorhabditis to understand the genetic background of the virus susceptibility of the host using CRISPR-mediated gene modifications. During my PhD, I collected sandflies and mosquitoes from nature to isolate and identify phleboviruses and flaviviruses which was followed by virus taxonomy and epidemiological studies.
研究兴趣
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Cigdem Alkan, Gautier Brésard,Lise Frézal,Aurélien Richaud, Albane Ruaud,Gaotian Zhang,Marie-Anne Félix
PLoS pathogensno. 6 (2024): e1012259-e1012259
Jonna B. Westover,Kie Hoon Jung,Cigdem Alkan, Kirsten M. Boardman,Arnaud J. Van Wettere, Craig Martens, Inioska Rojas,Philip Hicks,Aaron J. Thomas,Manohar T. Saindane,Gregory R. Bluemling,Shuli Mao,
JOURNAL OF VIROLOGYno. 4 (2024): e0013224-e0013224
Cigdem Alkan, Gautier Bresard,Lise Frézal,Aurélien Richaud, Albane Ruaud,Gaotian Zhang, Marie-Anne Felix
crossref(2024)
NPJ vaccinesno. 1 (2023): 171-16
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