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个人简介
My research focuses on the structural mechanisms and drug discovery in Alzheimer’s disease (AD), Hedgehog signaling and p53 in cancer, which have tremendous impact on human health. In AD, we are studying the structural mechanisms of the generation of amyloid-β peptide (Aβ). We also study the interaction between glycan and tau, which facilitates the spread of tau pathology, neurofibrillary tangle (NFT, the other pathological hallmark of AD). Another focus is the mechanisms of ApoE isoform which modulates AD risk. In cancer, we are studying the structural mechanism of Hedgehog signaling and p53 interactions.
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论文共 237 篇作者统计合作学者相似作者
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FRONTIERS IN MOLECULAR BIOSCIENCES (2024): 1386623-1386623
Sourav Samanta,Firoz Akhter,Anuradha Roy,Doris Chen, Benjamin Turner,Yongfu Wang,Nicolina Clemente,Chunyu Wang,Russell Howard Swerdlow,Kevin P Battaile,Scott Lovell, Shi Fang Yan,
Brain : a journal of neurologyno. 5 (2024): 1710-1725
Jiyuan Yang,Yuefan Song,Ke Xia,Vitor H Pomin,Chunyu Wang,Mingqiang Qiao, Robert J Linhardt,Jonathan S Dordick,Fuming Zhang
Marine drugsno. 5 (2024): 232
Glycoconjugate Journalno. 2 (2024): 1-12
Biomoleculesno. 10 (2023): 1445-1445
Daniel A Ciulla,Zihan Xu, John L Pezzullo,Patricia Dranchak,Chunyu Wang,José-Luis Giner,James Inglese,Brian P Callahan
Methods in enzymology (2023): 1-41
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