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个人简介
The hypothalamus in the brain is the converging point that integrates metabolic, neural, neuroendocrine, and neuroimmune signals to affect the whole body physiology. My research group is focusing on studying the roles of the hypothalamic immunity/inflammation cellular and molecular pathways in obesity and type 2 diabetes. We have discovered that in a hypercaloric environment the reactive microglia are important players in driving hyperphagia, adiposity and inappropriate glucose metabolism. We have also revealed the occurrence of hypothalamic angiogenesis in diet-induced obese mice as well as in postmortem hypothalamic tissue of patients with type 2 diabetes. Our research goal is to identify intracellular signaling pathways in the hypothalamic microglia that can be targeted by cell-specific compounds. By normalizing the dysfunctional hypothalamic microglial innate immunity, these compounds should be able to treat/prevent obesity & type 2 diabetes.
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Neuropharmacology (2024): 110029-110029
Ying Lei, Xian Liang,Yunong Sun,Ting Yao,Hongyu Gong,Zhenhua Chen,Yuanqing Gao,Hui Wang,Ru Wang, Yunqi Huang,Tao Yang,Miao Yu,
CELL METABOLISMno. 2 (2024): 438-453.e6
F. Correa Da Silva, C. M. M. Monteiro,M. J. Kalsbeek,I. Milanova,N. L. Korpel, L. Hoogendijk, C. J. V. Noesel, J. J. Gille,M. Sinnema,C. T. R. M. Schrander-Stumpel, L. M. Curfs,A. Kalsbeek,
GLIA (2023): E893-E893
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NANOTECHNOLOGY REVIEWSno. 1 (2023): 53-89
Felipe Correa-da-Silva,Martin J. Kalsbeek, Femke S. Gadella, Jorn Oppersma, Wei Jiang,Samantha E. C. Wolff,Nikita L. Korpel,Dick F. Swaab,Eric Fliers,Andries Kalsbeek,Chun-Xia Yi
Acta neuropathologica communicationsno. 1 (2023): 107-13
Eirini Vagena, Jasmina Crneta, Pauline Engstrom,Li He,Ernie Yulyaningsih,Nikita L. Korpel,Rachel T. Cheang,Tomas P. Bachor,Alyssa Huang, Guillermina Michel,Kush Attal,David Berrios,
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