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个人简介
Dr. Chunlong Chen (M) is an ATIP-Avenir Group Leader at Institut Curie. As a computational biologist, he has long-term experience in using high-throughput genomic approaches to address fundamental biology problems, with a particular interest in DNA replication and gene transcription regulation, and how deregulation of these processes challenges genome stability and leads to human diseases. During his post-doc training (CGM, CNRS), he has published several pioneer papers demonstrating the important roles of DNA replication in shaping the point mutation landscape of the human genome, which now has been included in the international projects to build an accurate model for identifying driver mutations, as well as revealing the mechanisms generating the point mutation signatures in cancers. His team now focuses on using both genomic approach (including single molecular/cell approaches) and genome-wide data analysis to study the DNA replication program and how its deregulation challenges genome stability, with both wet and dry lab expertise. The team has published several important papers revealing that gene transcription has an essential role in shaping the landscape of genome replication, while it is also a major source of endogenous replication stress inducing genome instability. He has been recognized as one of the leaders in the field, and being the recipient of an ATIP-Avenir (2018), a PIC3i program (2018) and two Emergent/High Risk project of the I. Curie (2020, 2021), three ANR grants (2019, 2021), one INCa grant (2019) and other grants. He received the Academy of Sciences’ AXA Award in 2012 and, in 2022, he is one of the winners of Impulscience® award of the Fondation Bettencourt Schueller. Since 2021, he is a member of national committee of CNRS in the section 21 and the interdisciplinary commission CID51.
研究兴趣
论文共 52 篇作者统计合作学者相似作者
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FRONTIERS IN GENETICSno. 15 Suppl (2023): 2315-24
Jian Li,Jiangqing Dong,Weitao Wang,Daqi Yu,Xinyu Fan, Yan Chit Hui,Clare S K Lee,Wai Hei Lam,Nathan Alary,Yang Yang,Yingyi Zhang, Qian Zhao,
Nature Structural & Molecular Biologyno. 4 (2023): 539-550
Stéphane Koundrioukoff,Su-Jung Kim,Nathan Alary, Antoine Toffano, Rodrigo Melendez-Garcia,Xia Wu,Yaqun Liu,Stefano Gnan,Sami El-Hilali,Olivier Brison,Filippo Rosselli,Chun-Long Chen,
biorxiv(2023)
Nucleic Acids Researchno. 4 (2022): e22-e22
Nucleic acids researchno. 12 (2021): e69-e69
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作者统计
#Papers: 52
#Citation: 4979
H-Index: 21
G-Index: 42
Sociability: 6
Diversity: 3
Activity: 126
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