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Bio
Graduated in Biochemsitry and Chemistry (1985) and received his Masters in Biochemistry (1988) at the University of Toronto. He received his PhD in Biochemistry from Universidade de São Paulo (1994) where he is now a Full Professor in the Department of Biochemistry. His research interests focus on understanding the structural basis of important biological and behavioral processes in bacteria using the phytopathogen Xanthomonas citri as a model. Specific systems under study are 1) signaling pathways involving the important second messenger cyclic diGMP that controls complex behaviours such as the production of virulence factors, motility and biofilm formation, 2) The structure and regulation of the type IV pilus, used by Xantthomonas to migrate across solid surfaces and to organize biofilm structures. 3) The Xanthomonas Type IV secretion system that mediates the transfer of bacterial toxins to the cells of other bacterial species, 4) Quorum sensing, the means by which members of a bacterial population coordinate their behavior in a manner dependent on cell density. His studies combine a variety of approaches including protein crystallography, Cryo-EM and NMR, other spectroscopic techniques, enzymology, fluorescence microscopy, the production and characterization of Xanthomonas knock-out strains and the analysis of protein interaction networks.
Research Interests
Papers共 133 篇Author StatisticsCo-AuthorSimilar Experts
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Tania Churasacari Vinces,Anacleto Silva de Souza, Cecília F. Carvalho, Aline Biazola Visnardi,Raphael D. Teixeira,Edgar E. Llontop, Beatriz Aparecida Passos Bismara,Elisabete J. Vicente, José O. Pereira,Robson Francisco de Souza,Mauricio Yonamine,Sandro Roberto Marana,
EMBO Reportsno. 3 (2024): 1436-1452
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Angy L. Dávalos,José D. Rivera,Denize C. Favaro,Ronaldo J. Oliveira, Gustavo PB. Carretero,Caroline D. Lacerda,Iolanda M. Cuccovia,Marcus V. C. Cardoso,Chuck S. Farah,Roberto K. Salinas
ACS Chemical Biologyno. 3 (2023): 669-686
Lidia dos Passos Lima, Juliana Biar Pereira, Anthony Jhoao Fasabi Flores,Alan Pericles Rodrigues Lorenzetti,Ana Laura Boechat, Maria Claudia Pereda, Sophia Gualtieri, Daniele Ferreira do Prado,Diego Rocha,Lucas de Moraes Ceseti,Regina Lucia Baldini,Chuck S. Farah,
crossref(2022)
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