基本信息
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Career Trajectory
Bio
Research Interests
Drug discovery:
New strategies for peptide and protein drug development; peptide drug delivery; peptide and protein bioconjugates and antibody-drug conjugates as drug modalities; new peptide leads from phage display and natural sources.
Medicinal chemistry and structure-based drug design; peptidomimetics; combinatorial chemistry for drug lead discovery.
Development and use of peptide nucleic acid analogs as antisense and antigene agents.
Pharmacokinetic (PK) studies using LC-MS.
Peptide/protein chemistry and chemical biology:
Development of chemical/enzymatic peptide ligation methods and site-specific protein modification methods; use of protein chemical synthesis for the study of protein structure and functions; study of ubiquitin biology and structural biology using homogeneous chemically ubiquitinated proteins; study of chromatin structure and biology using semisynthetic histones carrying various PTMs.
Drug discovery:
New strategies for peptide and protein drug development; peptide drug delivery; peptide and protein bioconjugates and antibody-drug conjugates as drug modalities; new peptide leads from phage display and natural sources.
Medicinal chemistry and structure-based drug design; peptidomimetics; combinatorial chemistry for drug lead discovery.
Development and use of peptide nucleic acid analogs as antisense and antigene agents.
Pharmacokinetic (PK) studies using LC-MS.
Peptide/protein chemistry and chemical biology:
Development of chemical/enzymatic peptide ligation methods and site-specific protein modification methods; use of protein chemical synthesis for the study of protein structure and functions; study of ubiquitin biology and structural biology using homogeneous chemically ubiquitinated proteins; study of chromatin structure and biology using semisynthetic histones carrying various PTMs.
Research Interests
Papers共 135 篇Author StatisticsCo-AuthorSimilar Experts
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 14 (2024): e202317789-e202317789
Biomedicinesno. 11 (2023): 3080-3080
ADC review (2023)
Shining Loo,Antony Kam, Bamaprasad Dutta,Xiaohong Zhang,Nan Feng,Siu Kwan Sze,Chuan-Fa Liu,Xiaoliang Wang,James P Tam
bioRxiv (Cold Spring Harbor Laboratory) (2023)
New Phytologistno. 2 (2023): 765-780
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