He leads a team of over 60 clinical and research scientists and students that have been undertaking neuroimaging and neuropsychological work in schizophrenia and psychosis, and other psychiatric and neurodegenerative disorders since 1993 in Australia. His work has focused on brain structural and functional changes during the transition to psychosis. His group was the first to describe progressive brain structural changes at psychosis onset, with a seminal paper published in The Lancet in 2003. He has published over 500 papers and chapters, including papers in high-profile international psychiatry, neurology, radiology and medical journals. He published one of the first books on the neuropsychology of schizophrenia, a recently published book on “Olfaction and the Brain” and a book on “The Neuropsychology of Mental Illness”. He has established a unique resource of over 5,000 multimodal brain scans in patients with schizophrenia and other neuropsychiatric disorders, including longitudinal imaging. Recent work focuses on early developmental disorders, including children with schizotypal features and autism. Professor Pantelis has won a number of NHMRC grants, including four recent international collaborative EU-NHMRC grants and was a CI on a national NHMRC Enabling Grant to establish the Australian Schizophrenia Research Bank (ASRB). He was co-Chief Investigator on a NHMRC Program Grant, which commenced in 2005 (2005-2009: $7.4 million) and focuses on the neurobiology of emerging severe mental illness during late brain development. This grant was refunded for a further 5 years commencing (2009-2013: >$10 million). He is an investigator on a $23 million CRC grant examining biomarkers in neurodegenerative and psychotic disorders. In 2003 he won the Selwyn-Smith Medical Research Prize of The University of Melbourne for his work on progressive brain changes in early psychosis and, most recently, he was highly commended in the 2009 Victorian Minister of Health Award for Outstanding Individual Achievement in Mental Health. He was awarded an NHMRC Senior Principal Research Fellowship, which commenced in 2010, renewed until 2020. He was awarded a 2011 NARSAD Distinguished Investigator Grant from the Brain & Behavior Research Foundation (US). He was awarded the international 2013 Robert-Sommer Award from the Justus Liebig University School of Medicine, Germany. He was conferred a Doctor Honoris Causa from the National and Kapodistrian University of Athens in 2015. He was named in the Thomson Reuters list of “The World’s Most Influential Scientific Minds” for 2014, 2015 and 2016, representing the top 1% of most highly cited scientists in his field. He is on the Editorial Boards of national and international journals, including Associate Editor for Psychological Medicine.