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个人简介
During the early 1970's he was the first person to demonstrate that cell-mediated immunity and antibody formation are mutually antagonistic responses, an observation that underpins the Th1/Th2 paradigm in immunology. He is currently attempting to harness immune deviation to produce novel anti-cancer vaccines. Since the late 1970's Professor Parish has also been interested in the role that complex carbohydrates, particularly heparan sulfate, play in cell adhesion and cell migration. These studies have resulted in heparanase, the enzyme that degrades heparan sulfate, being identified as a drug target and has formed the theoretical basis for the development of several carbohydrate-based drugs, such as PI-88 (Muparfostat), that inhibit inflammation, tumour metastasis and angiogenesis. In addition, Professor Parish’s laboratory has developed a number of important immunological techniques, such as fluorescent dyes (e.g., CFSE) for monitoring lymphocyte migration and proliferation. His research findings underpin several Australian biotechnology companies, such as Progen Pharmaceuticals and Lipotek. In 2005 Prof Parish was awarded the Clive and Vera Ramaciotti Medal for Excellence in Biomedical Research in recognition of his scientific achievements.
研究兴趣
论文共 7 篇作者统计合作学者相似作者
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Lucy A Coupland, Calista Spiro,Benjamin J-C Quah, Anna Orlov,Anna Browne, Connor H O'Meara, Chang-Won Kang, Steve Frost, Luis Schulz,Lien Lombardo,Christopher R Parish,Anders Aneman
Shock (Augusta, Ga.) (2024)
Journal of Biological Chemistryno. 10 (2005): 8842-8849
Nature immunologyno. 9 (2005): 861-2
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