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Bio
Research in the Schofield group aims to contribute to a chemical understanding of biological systems, where possible of medicinal or agricultural importance. We have a particular interest in metallo-enzymes that are included in antibiotic biosynthesis and resistance as well as in human physiology. The iron and zinc dependent enzymes we study are of intrinsic chemical interest because they can catalyse reactions presently impossible for synthetic chemistry. Some of them also play roles in human physiology and disease, e.g. in enabling us to respond to limiting oxygen availability and to repair damage to our DNA. We are presently interested in understanding the details of how environmental factors regulate gene expression, with a particular focus on oxygen regulated processes. We are a highly collaborative group, often working with researchers in academia and industry. A major current focus is working in the Ineos Oxford Institute for Antimicrobial Resistance to combat antibacterial resistance both in human and farming applications.
Research Interests
Papers共 1092 篇Author StatisticsCo-AuthorSimilar Experts
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Anandhu Krishnan,Sodiq O. Waheed,Ann Varghese, Fathima Hameed Cherilakkudy,Christopher J. Schofield,Tatyana G. Karabencheva-Christova
Chemical Scienceno. 10 (2024): 3466-3484
Zihao Wang, Guodong Cao,Miranda P. Collier,Xingyu Qiu,Sophie Broadway-Stringer,Dominik Šaman, Jediael Z.Y. Ng, Navoneel Sen,Amar J. Azad,Charlotte Hooper,Johannes Zimmermann,Michael McDonough,
biorxiv(2024)
Hannah Lawson,James P Holt-Martyn,Vilma Dembitz,Yuka Kabayama, Lydia M Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon,Jozef Durko,Louie N van de Lagemaat, Azzura L De Pace,Anthony Tumber,
Nature cancerno. 6 (2024): 916-937
Takashi Miura,Tika R Malla,Lennart Brewitz,Anthony Tumber,Eidarus Salah, Kang Ju Lee,Naohiro Terasaka,C David Owen,Claire Strain-Damerell,Petra Lukacik,Martin A Walsh,Akane Kawamura,
Bulletin of the Chemical Society of Japanno. 5 (2024): uoae018-uoae018
CHEMICAL SCIENCEno. 7 (2024): 2509-2517
RSC CHEMICAL BIOLOGYno. 2 (2024): 117-130
Current opinion in chemical biology (2024): 102428-102428
Journal of Biological Chemistrypp.107546-107546, (2024)
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