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We aim to understand the code for RNA splicing: how the precise locations of introns and splice sites are identified in primary transcripts and how its specificity changes in different cell types. Toward this end, we are mapping the RNA-binding affinity spectra of dozens of human RNA-binding proteins and integrating this information with in vivo binding and activity data. We are also studying the functions of 3’ untranslated regions, including their roles in mRNA localization and microRNA regulation. The lab uses a combination of computational and experimental approaches to address these questions.
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论文共 40 篇作者统计合作学者相似作者
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Eric T Wang,Daniel Treacy,Katy Eichinger,Adam Struck,Joseph Estabrook,Hailey Olafson,Thomas T Wang,Kirti Bhatt, Tony Westbrook, Sam Sedehizadeh,Amanda Ward,John Day,
Marina Vidaki,Frauke Drees,Tanvi Saxena, Erwin Lanslots,Matthew J Taliaferro, Antonios Tatarakis,Christopher B Burge,Eric T Wang,Frank B Gertler
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