基本信息
浏览量:26
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
The nervous system and the immune system are the two large sensory units of the body, which perpetually monitor tissue integrity and mount effector responses upon disturbance of tissue hemostasis. However, how these two sensory systems exchange information and coordinate tissue protective responses remains elusive. Our research has recently exposed signaling pathways, by which the nervous system regulates innate lymphoid cells (ILCs) and type 2 immune responses via the production of neuropeptides (neuromedin U) and neurotransmitters (norepinephrine). ILCs are an emerging population of tissue-resident innate immune cells enriched at mucosal barriers, which can mount either protective or detrimental immune response at barrier surfaces. While we begin to understand some of the tissue-specific cues, which regulate immune activation at barrier surfaces, neuronal regulation of immune responses is still almost a black box. In order to systematically investigate neuro-immune crosstalk at mucosal surfaces in health and disease, we have developed elegant genetic tools, which allow experimental manipulation of neurons and ILCs. Taken together, combing cutting-edge technologies in the fields of immunology, neuroscience and genomics, will enable us to conceptually understand neuro-immune interaction and uncover signaling pathways that have the potential to be therapeutically harnessed.
研究兴趣
论文共 48 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
NATURE REVIEWS IMMUNOLOGYno. 4 (2024): 294-302
Xiaogang Feng, Tilde Andersson,Julia Gschwend,Pascal Flüchter, Ivan Berest, Julian L. Muff, Daniele Carchidi, Antonie Lechner, Jeshua C. de Tenorio, Nina Brander,Ulrich Boehm,Christoph S. N. Klose,
biorxiv(2024)
Ivo Röwekamp, Laura Maschirow,Anne Rabes,Facundo Fiocca Vernengo,Lutz Hamann,Gitta Anne Heinz,Mir-Farzin Mashreghi,Sandra Caesar,Miha Milek, Anna Carolina Fagundes Fonseca,Sandra-Maria Wienhold,Geraldine Nouailles,
Proceedings of the National Academy of Sciences of the United States of Americano. 22 (2024): e2310864121-e2310864121
Frontiers in immunology (2023): 1294936
The Journal of investigative dermatologyno. 12 (2023): 2456-2467.e5
crossref(2022)
加载更多
作者统计
#Papers: 48
#Citation: 6443
H-Index: 23
G-Index: 35
Sociability: 6
Diversity: 3
Activity: 112
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn