基本信息
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Career Trajectory
Bio
C. Pourcel started her career at the Pasteur Institute in 1975 and has since been involved in public health research in the field of virology and bacteriology, with the aim to associate basic science and applications. She first worked on the development of Lambda phage derivatives as vectors to clone DNA fragments. She then used one of these vectors to clone the hepatitis B virus (HBV) genome. Together with Marie-Françoise Dubois they were the first to obtain the expression of the virus surface antigen HBsAg in cultured cells, the pioneer work that led to the production of a recombinant vaccine.
C. Pourcel then performed a Postdoctoral internship in Jesse Summers’ laboratory In Philadelphia where she made key observations on the duck hepatitis B virus replication cycle. Back to the Institut Pasteur she collaborated with Charles Babinet to produce the first transgenic mice in France. They were able to obtain mice containing the HBV genome in which the full virus cycle was observed and which expressed HBsAg, allowing the creation of an animal model for the chronic infection. C. Pourcel observed that de novo methylation of the transgene influenced the gene expression and described its role in maternal imprinting.
Later she was involved in different projects related to xenotransplantation and autoimmunity, again using transgenic animals as models.
In 2003 C. Pourcel left the Pasteur Institute to study the genetic diversity of bacterial pathogens at the Université Paris-Sud with Gilles Vergnaud. She developed tools to genotype different species and performed epidemiologic studies in collaboration with scientists in several French hospitals. An important consequence of this line of work was the discovery of the function of CRISPR-Cas systems published in 2005.
Since 2009 C. Pourcel has concentrated her efforts in isolating and characterizing bacteriophages with the aim to understand their coevolution with their host and to possibly use them for phage therapy. She is particularly interested in the mechanisms that bacteria use to resist their predators both naturally in the environment and in the laboratory following infection. She uncovered the importance of pseudolysogeny in the emergence of bacterial resistance to lytic phages.
Christine Pourcel is the author of 170 publications.
Research Interests
Papers共 200 篇Author StatisticsCo-AuthorSimilar Experts
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Archives of Virologyno. 7 (2023): 187-7
Christiane Essoh,Jean-Philippe Vernadet,Gilles Vergnaud,Adama Coulibaly,Adèle Kakou-N’Douba, Assavo S.-P. N’Guetta, Thimotée Ouassa,Christine Pourcel
Kimberley Houenoussi, Roudaina Boukheloua,Jean-Philippe Vernadet,Daniel Gautheret,Gilles Vergnaud,Christine Pourcel
biorxiv(2020)
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Author Statistics
#Papers: 199
#Citation: 15555
H-Index: 51
G-Index: 124
Sociability: 7
Diversity: 3
Activity: 14
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