Christian Joerg Braun
研究员
Department of Pediatrics
Dr. von Hauner Children's Hospital, University Hospital, Ludwig Maximilians University of Munich (LMU)/Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technische Universität München/Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ)
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We are trying to understand what mechanisms are employed by childhood cancers to fuel their oncogenic signaling machinery. In order to do so, we employ state of the art model systems for pediatric tumors, high-throughput CRISPR and RNAi screens, comprehensive analyses of transcriptional landscapes as well as customized experimental pipelines for the establishment of biomarker profiles.
Our group is particularly interested in discovering and characterizing new targetable vulnerabilities to advance the therapy of pediatric nervous system tumors such as glioma and neuroblastoma.
All classes of cellular RNAs are subject to direct and post-transcriptional modification. RNA binding proteins (RBPs) specifically recognize many of these modifications and consecutively influence RNA stability, alternative splicing, location and decay. There is emerging evidence that both developing tissues and cancer cells utilize these ‘epitranscriptional’ processes to orchestrate gene expression profiles in a coordinated fashion (Braun and Hemann, Curr Opin Genet Dev, 2019).
Not surprisingly, core ‘epitranscriptional’ regulators such as splice factors are frequently subject to mutation in cancer. We have previously found that the splicing rate of specific introns contributes to gene expression orchestration in both physiology and cancer. Intriguingly, this process represents a targetable vulnerability (Braun et al., Cancer Cell, 2017).
Our lab is interested in deeper characterizing this observation and in systematically analyzing the role of post-transcriptional RNA biology in childhood cancer.
Our group is particularly interested in discovering and characterizing new targetable vulnerabilities to advance the therapy of pediatric nervous system tumors such as glioma and neuroblastoma.
All classes of cellular RNAs are subject to direct and post-transcriptional modification. RNA binding proteins (RBPs) specifically recognize many of these modifications and consecutively influence RNA stability, alternative splicing, location and decay. There is emerging evidence that both developing tissues and cancer cells utilize these ‘epitranscriptional’ processes to orchestrate gene expression profiles in a coordinated fashion (Braun and Hemann, Curr Opin Genet Dev, 2019).
Not surprisingly, core ‘epitranscriptional’ regulators such as splice factors are frequently subject to mutation in cancer. We have previously found that the splicing rate of specific introns contributes to gene expression orchestration in both physiology and cancer. Intriguingly, this process represents a targetable vulnerability (Braun et al., Cancer Cell, 2017).
Our lab is interested in deeper characterizing this observation and in systematically analyzing the role of post-transcriptional RNA biology in childhood cancer.
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Adaobi Mofunanya, Eleanor R Cameron,Christian J Braun, Frank Celeste,Xiaoyu Zhao,Michael T Hemann,Kenneth L Scott,Jinyu Li,Scott Powers
Scientific reportsno. 1 (2024): 13227-13227
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