Our group aims to understand the cellular immunity to viral infections in different disease contexts. Using complementary tools for immune analysis and integrated -omics approaches, we seek to identify functional correlates of virus control and to explore their underlying cellular and molecular mechanisms. We combine immune assays with methylome, communicome and transcriptomics analyses to assess to what degree and at which stages of different viral infections the effector function profiles of virus-specific T cells are epigenetically controlled. We are especially interested in understanding these mechanisms in lympho-proliverative and neurological diseases driven by these viral infections.