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Christian Andrea Di Buduo has consolidated experience in research on megakaryopoiesis. Since 2009, his main research interest has been focused on unraveling how soluble factors, extracellular environment, and intracellular signalings integrate to promote megakaryocyte functions. Specifically, he demonstrated that autocrine signals, together with TPO, activate ion flows and biochemical pathways that finely regulate platelet formation and megakaryocyte sensing of the extracellular environment, and that any alteration of these mechanisms may lead to pathologic phenotypes (e.g., Inherited Thrombocytopenias, Myeloproliferative Neoplasms).
In an effort to try to better translate these laboratory results to clinic, he contributed to the development of the first silk-based bone marrow tissue model, that can faithfully mimic the bone marrow niche for ex vivo production of human platelets to be used in transfusion and regenerative medicine (Patent n. WO2016022834 A1) and testing of human-specific drugs (Patent n. WO2021113830A1). Of note, these systems were successfully used to mimic pathologic megakaryopoiesis by taking advantage of in vitro differentiated megakaryocytes from patients.
Research Interests
Papers共 78 篇Author StatisticsCo-AuthorSimilar Experts
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Christian Andrea Di Buduo, Marco Lunghi, Volodymyr Kuzmenko,Pierre‐Alexandre Laurent, Giulia Della Rosa,Claudia Del Fante, Damian Edward Dalle Nogare, Florian Jug,Cesare Perotti, Koji Eto,Alessandro Pecci,Itedale Namro Redwan,
Advanced Scienceno. 18 (2024)
AMERICAN JOURNAL OF HEMATOLOGYno. 3 (2024): 336-349
Christian Andrea Di Buduo, Marco Lunghi,Volodymyr Kuzmenko,Pierre-Alexandre Laurent, Giulia Della Rosa,Claudia Del Fante, Damian Edward Dalle Nogare, Florian Jug,Cesare Perotti,Koji Eto,Alessandro Pecci,Itedale Namro Redwan,
ADVANCED SCIENCEno. 18 (2024): e2308276-e2308276
Alberto Bocconi,Christian Andrea Di Buduo, Giulia Della Rosa,Manuela Teresa Raimondi,Alessandra Balduini
TISSUE ENGINEERING PART Ano. 13-14 (2023)
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Eman Khatib-Massalha,Ya-Hsuan Ho,Elodie Grockowiak, Yuki Date, Lam Tan Khuat,Zijian Fang, Eva Carrillo Felez,Christian Di Buduo,Alessandra Balduini,Simon Mendez-Ferrer
BLOOD (2023): 515
International journal of molecular sciencesno. 6 (2023): 5157-5157
Research and Practice in Thrombosis and Haemostasisno. 4 (2023): 100197-100197
Plateletsno. 1 (2023): 2176699-2176699
JOURNAL OF THROMBOSIS AND HAEMOSTASISno. 11 (2023): 3078-3081
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