基本信息
views: 4
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Research synopsis
Cell growth and integrity require membrane growth and integrity. We are using cross-disciplinary approaches to elucidate vital roles of inter-organelle contacts in membrane biogenesis and homeostasis at the molecular, ultra-structural, cellular, and tissue levels. Inter-organelle contacts serve as key sites for the coordinated regulation of membrane lipid metabolism and transport. Our studies have focused on contacts between the endoplasmic reticulum and the plasma membrane (ER-PM contacts), providing new understanding of membrane lipid and calcium dynamics during regulated exocytosis and polarised secretion. We are currently examining ER-PM contact architecture and function in hepatocytes, polarised epithelial cells of the liver. These investigations are suggesting new strategies to control biliary secretion that may prove beneficial in the treatment of liver disease.
Furthermore, we are probing how alterations in inter-organelle contacts and membrane lipid homeostasis result in organelle damage. These studies are revealing novel protective pathways that sense and respond to membrane stress conditions to ensure membrane integrity and organelle homeostasis. Numerous diseases are caused by imbalances in membrane lipid homeostasis including cancer, diabetes, and neurodegenerative disorders. We expect our investigations will identify new targets and strategies for the treatment of diseases caused by disruptions in membrane lipid and organelle homeostasis.
Cell growth and integrity require membrane growth and integrity. We are using cross-disciplinary approaches to elucidate vital roles of inter-organelle contacts in membrane biogenesis and homeostasis at the molecular, ultra-structural, cellular, and tissue levels. Inter-organelle contacts serve as key sites for the coordinated regulation of membrane lipid metabolism and transport. Our studies have focused on contacts between the endoplasmic reticulum and the plasma membrane (ER-PM contacts), providing new understanding of membrane lipid and calcium dynamics during regulated exocytosis and polarised secretion. We are currently examining ER-PM contact architecture and function in hepatocytes, polarised epithelial cells of the liver. These investigations are suggesting new strategies to control biliary secretion that may prove beneficial in the treatment of liver disease.
Furthermore, we are probing how alterations in inter-organelle contacts and membrane lipid homeostasis result in organelle damage. These studies are revealing novel protective pathways that sense and respond to membrane stress conditions to ensure membrane integrity and organelle homeostasis. Numerous diseases are caused by imbalances in membrane lipid homeostasis including cancer, diabetes, and neurodegenerative disorders. We expect our investigations will identify new targets and strategies for the treatment of diseases caused by disruptions in membrane lipid and organelle homeostasis.
Research Interests
Papers共 116 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Scientific Reportsno. 1 (2024): 1-10
Ian Davis, Jackie M Payne,Victoria L Olguin, Madison P Sanders,Tamara Clements,Christopher P Stefan,Janice A Williams,Jay W Hooper,John W Huggins,Eric M Mucker,Keersten M Ricks
Frontiers in microbiology (2023): 1243523-1243523
Open Forum Infectious Diseasesno. Supplement_2 (2022)
Load More
Author Statistics
#Papers: 115
#Citation: 5529
H-Index: 33
G-Index: 74
Sociability: 6
Diversity: 0
Activity: 1
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn