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Infection by Plasmodium falciparum causes 1-2 million childhood deaths per annum in Sub-Saharan Africa alone. This virulence is due to a high rate of multiplication and the alteration of the host erythrocyte membrane.
Some parasite proteins, encoded by large variant multigene families, are inserted into the membrane and are accessible from the exterior. Parasitised red cells then concentrate in various organs and cause damage by binding to endothelial cells, to other red cells forming rosettes which may reduce blood flow, or to dendritic cells inhibiting their activation. Switching between different members of the multi-gene families allows the parasite to evade the protective antibody response.
Some parasite proteins, encoded by large variant multigene families, are inserted into the membrane and are accessible from the exterior. Parasitised red cells then concentrate in various organs and cause damage by binding to endothelial cells, to other red cells forming rosettes which may reduce blood flow, or to dendritic cells inhibiting their activation. Switching between different members of the multi-gene families allows the parasite to evade the protective antibody response.
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Jedida Mwacharo, Matt Berriman,Jean Langhorne,Francis M. Ndungu,Kevin Marsh,Jennifer Musyoki,John W.G. Addy, John Joseph Valletta,Joyce Mwongeli Ngoi,Philip Bejon,Yaw Bediako,Mario Recker,
Wellcome Open Research (2022)
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Wellcome open research (2019): 193-193
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