基本信息
浏览量:67
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Metastasis is responsible for over 90% of cancer-related deaths. For cancer cells to spread, they need to adapt to the tissue environment they encounter. On their journey they will meet obstacles of various physical properties, and the cancer cells have therefore developed strategies to circumvent these challenges, a term known as ‘plasticity of cell migration’.
Importantly the plasticity of cell migration can affect the ability of cancer cells to metastasise, and the failure of many anti-metastatic drugs can be explained by the ability of cancer cells to change mode of migration. While the intrinsic mechanisms behind cell migration are well studied, the challenge now is to understand how the extracellular environment regulates this machinery to maintain efficient movement. The extracellular matrix (ECM) provides critical topological, mechanical and biochemical cues to the cells and consequently one of the most important regulators of cellular and tissue function in the body. In most solid tumours the ECM is substantially transformed leading to cancer progression and dissemination. This transformation is often crafted by activated cancer-associated fibroblasts (CAFs). The aim of our research is to decode the way cancer cells navigate in topographically distinct environments. We aim at understanding the pathological changes occurring in the tumour ECM, and how de-activation of CAFs can counteract these alterations and ultimately stop the spread of cancer.
研究兴趣
论文共 48 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Marco A. Briones-Orta,Laurence Levy,Chris D. Madsen, Debipriya Das, Yigit Erker,Erik Sahai,Caroline S. Hill
crossref(2023)
Marco A. Briones-Orta,Laurence Levy,Chris D. Madsen, Debipriya Das, Yigit Erker,Erik Sahai,Caroline S. Hill
crossref(2023)
Marco A. Briones-Orta,Laurence Levy,Chris D. Madsen, Debipriya Das, Yigit Erker,Erik Sahai,Caroline S. Hill
crossref(2023)
Marco A. Briones-Orta,Laurence Levy,Chris D. Madsen, Debipriya Das, Yigit Erker,Erik Sahai,Caroline S. Hill
crossref(2023)
Marco A. Briones-Orta,Laurence Levy,Chris D. Madsen, Debipriya Das, Yigit Erker,Erik Sahai,Caroline S. Hill
crossref(2023)
Marco A. Briones-Orta,Laurence Levy,Chris D. Madsen, Debipriya Das, Yigit Erker,Erik Sahai,Caroline S. Hill
crossref(2023)
Marco A. Briones-Orta,Laurence Levy,Chris D. Madsen, Debipriya Das, Yigit Erker,Erik Sahai,Caroline S. Hill
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn