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职业迁徙
个人简介
He applied the single-molecule FRET technique to mechanistic studies on the target search process of microRNA and CRISPR/Cas9 and the single-molecule pull-down method to the functional studies of protein complexes in microRNA biogenesis and CRISPR memory formation. His single-molecule studies were/are supported by ERC Starting Grant (microRNA, 2012-2017), NWO Vidi (CRISPR, 2015-2020), and ERC Consolidator Grant (DNA elimination, 2019-2024).
In 2017, Chirlmin Joo took leadership of developing new techniques of 'single-molecule protein sequencing' in a Dutch national science program (NWO-FOM Vrije Programme). His team aims at developing high-resolution single-molecule techniques that can, for the first time, determine protein sequences at the single-molecule level. Using single-molecule fluorescence and nanopores, his team is exploring the biophysics of protein translocation and will utilize it to develop a novel technology to determine the sequence of proteins. By analyzing proteins molecule by molecule, his team will be able to read the entire proteome, despite its complex nature and the wide dynamic range of abundances of cellular proteins. The new technology will be the first to create the opportunity for single-cell proteomics and real-time screening for on-site medical diagnostics.
研究兴趣
论文共 124 篇作者统计合作学者相似作者
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Nature Nanotechnologypp.1-8, (2024)
Sungchul Kim, Yong-geun Choi, Kirsten Janssen,Christian Bull, Bhagyashree S. Joshi,Adam Pomorski,Vered Raz, Marvin E. Tanenbaum,Pascal Miesen,Zeshi Li,Chirlmin Joo
biorxiv(2024)
biorxiv(2023)
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EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2023): S30-S30
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Carolien Bastiaanssen, Pilar Bobadilla Ugarte,Kijun Kim,Yanlei Feng,Giada Finocchio, Todd A. Anzelon,Stephan Kostlbacher,Daniel C. Tamarit,Thijs J.G. Ettema,Martin Jinek,Ian J. MacRae,Chirlmin Joo,
biorxiv(2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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iScienceno. 2 (2023): 105958-105958
Methods in molecular biologypp.203-213, (2023)
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