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Bio
I am a human geneticist by training and am board certified in both clinical cytogenetics and clinical molecular genetics by the American Board of Medical Genetics since 1993. Professionally, I served as the Director Clinical Cytogenetics Laboratory at Stanford University and Washington University in my early career, but I have been devoted to basic research throughout my career since graduate school.
What I would bring to the current proposed project is an extensive experience from genetic and epigenetic studies of nuclear and mitochondrial genomes using novel experimental systems and methods to understand normal, neoplastic, and aging processes in humans. Interacting with clinicians from many specialties for disease diagnosis and treatment management as a clinical cytogenetics laboratory director provided me a broad perspective in human biology beyond the view of a basic science researcher. This broad-based understanding and perspective in biological processes and medicine have kept me mindful of the overall complexity of human biology while I focus on answering key questions with experimental tools throughout my career.
My primary research interests include cancer genetics; function and mechanism of epigenetic regulation; DNA damage and genomic aberrations; mitochondrial genetics and biology; stem cell biology; and human aging. Through my experience in these areas, 1) I have been one of the founding members of the International Consortium of Prostate Cancer Genetics (ICPCG) that has been funded by NCI for over 20 years to discover genetic causes of familial prostate cancer; 2) I have developed a novel system to study the function of DNA methylation in human cells and advance the understanding of this epigenetic mechanism in human biological processes and its interplay with histones for more than two decades; 3) I have collaborated with other scientists to study chromosomal translocations and aging relate to DNA damage, primarily due to double-strand DNA breaks; 4) I have answered key question in human population gene admixture using nuclear and mitochondrial markers, clearly ruling out the presence of DNA methylation in human mitochondrial DNA, and contributed to the understanding of mitochondrial DNA replication; and 5) our team was one of the first to documented evidence of the accumulation of DNA damage with age in humans, and we developed novel methods to examine DNA mutations comprehensively by whole genome sequencing in tissue specific stem cells to understand the key aspects of human aging.
Research Interests
Papers共 97 篇Author StatisticsCo-AuthorSimilar Experts
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BMC research notesno. 1 (2023): 66-6
Heather A. Ogana,Samantha Hurwitz,Chih-Lin Hsieh,Huimin Geng, Markus Müschen,Deepa Bhojwani, Mark A. Wolf, James Larocque,Michael R. Lieber,Yong Mi Kim
Frontiers in Oncology (2021)
Yongsheng Ruan,Hye Na Kim,Heather A. Ogana,Zesheng Wan,Samantha Hurwitz,Cydney Nichols,Nour Abdel-Azim,Ariana Coba, Seyoung Seo, Yong-Hwee Eddie Loh,Eun Ji Gang,Hisham Abdel-Azim,
Frontiers in Oncology (2021)
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