基本信息
浏览量:0
职业迁徙
个人简介
Dr. Chen’s research focuses on stem cell biology and stem cell-based therapy for craniofacial and immune-related diseases, in which several novel physiological mechanisms have been identified. These findings have been translated into several pilot clinical studies to treat human patients with autoimmune diseases such as Systemic Lupus Erythematosus and Systemic Sclerosis; however, the reasons behind this stem cell-based therapy are not fully understood. As a secretome, mesenchymal stem cells (MSCs) release large amounts of cytokines and small vesicles for immunoregulation and communication with surrounding cells. The major goal of Dr. Chen’s current studies is to investigate how small vesicles are controlled by a set of membrane traffic proteins for cell component reuse in stem cell transplantation.
Dr. Chen is also interested in bone biology and dissects the role of MSCs in bone/marrow homeostasis. He focuses on aging which leads a deterioration of the physiological systems and is a paradigmatic example of homeostasis collapse. Changes in histone modifications have been linked to stabilizing nuclear F-actin scaffold and actomyosin contractility, suggesting that nuclear size and shape may be regulated by specific histone signatures. The major goal of these studies is to investigate how MSCs participate in rejuvenation of senescent cells via histone modifications.
Recently, Dr. Chen is involved in oral cancer research to identify the physiological roles of cancer stem cells, stromal populations, and immune components in tumor microenvironment through single cell transcriptomic analysis. Upon successful determination of oral cancer biomarkers, the capacities of diagnosis, treatment, and tumor margin identification will be largely improved in head and neck cancer. Dr. Chen’s research is currently supported by the NIH/NIDCR.
Dr. Chen is also interested in bone biology and dissects the role of MSCs in bone/marrow homeostasis. He focuses on aging which leads a deterioration of the physiological systems and is a paradigmatic example of homeostasis collapse. Changes in histone modifications have been linked to stabilizing nuclear F-actin scaffold and actomyosin contractility, suggesting that nuclear size and shape may be regulated by specific histone signatures. The major goal of these studies is to investigate how MSCs participate in rejuvenation of senescent cells via histone modifications.
Recently, Dr. Chen is involved in oral cancer research to identify the physiological roles of cancer stem cells, stromal populations, and immune components in tumor microenvironment through single cell transcriptomic analysis. Upon successful determination of oral cancer biomarkers, the capacities of diagnosis, treatment, and tumor margin identification will be largely improved in head and neck cancer. Dr. Chen’s research is currently supported by the NIH/NIDCR.
研究兴趣
论文共 2 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
biorxiv(2021)
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn