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Our laboratory is working to understand the mechanisms by which genes regulate body composition, using cell-based approaches, genetically engineered mouse models and genomic technologies to dissect the complex interrelationships among gene products and their effects on adiposity and metabolism. Several of these gene products are members of the TGF-beta family, which has been our main focus for several years. Our team’s ultimate goal is to understand the variety of mechanisms by which genes affect adiposity in humans thereby providing the basis for the rational design of drugs for the medical treatment of obesity and its co-morbidities. Accordingly, our clinical interests include a variety of genetic syndromes, particularly those with obesity as a feature, and the contributions of genomic copy number variation and monogenic variants to syndromic and non-syndromic obesity. I am certified by the American Board of Medical Genetics and have been in Clinical Genetics practice since 1996. We have also been a communicating or coauthor on several publications reporting the cause of a variety of genetic conditions.
We seek to understand gene functions that have important effects on energy metabolism by influencing the metabolic rate, fat cell differentiation, growth and function. We use mouse model systems and cell culture approaches to understand these processes. Clinically, we are now applying emerging genomic technologies to benefit patients, and our collaborations will allow us to develop several lines of translational study, not only related to obesity and metabolism, but also to better understand the genomic basis of HIV and TB susceptibility and progression and other conditions in African children, while building the capacity and infrastructure for African scientists to carry out such studies independently through the H3 Africa initiative. These efforts hold substantial promise to establish collaborations with several African institutions and to benefit patients on many fronts. Human subjects research is a significant change in focus for our lab, a decision made because of the clinical importance of the problems, the importance of ethical and culturally sensitive practices for genomic science abroad as we seek to impact global health, and my responsibilities as a physician scientist. Collectively, our team has many years of experience in the clinical, molecular and statistical aspects that are critical for the success of future projects both at home and abroad.
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论文共 83 篇作者统计合作学者相似作者
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Erin Thorpe, Taylor Williams,Chad Shaw, Evgenii Chekalin,Julia Ortega,Keisha Robinson, Jason Button,Marilyn C Jones,Miguel Del Campo,Donald Basel,Julie McCarrier, Laura Davis Keppen,
American journal of human geneticsno. 7 (2024): 1271-1281
BRAIN SCIENCESno. 2 (2024): 179
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2024): 132-140
Ryan J. Taft,Erin Thorpe, Taylor Williams,Chad A. Shaw, Evgenii Chekalin,Julia Ortega,Keisha D. Robinson, Jason Button,Marilyn C. Jones,Miguel del Campo,Donald Basel,Julie McCarrier,
Research Square (Research Square) (2023)
bioRxiv the preprint server for biology (2023)
Ryan Taft,Erin Thorpe,John Belmont, Taylor Williams,Chad Shaw, Jason Button,Julia Ortega,Keisha Robinson,Marilyn Jones,Diane Masser-Frye,Donald Basel,Chester Brown,
Genetics in Medicine Openno. 1 (2023): 100464-100464
Chester Brown,Robert Rooney,Sandra Arnold,Robert Davis, Carol Hendrix,Akram Mohammed,Janet Zink,David Hains, Kito Lord,Dennis Black,Marie Jackson, Andrew Griffith,
Ian D. Krantz,Livija Medne, Jamila M. Weatherly, Taylor Wild,Sawona Biswas,Batsal Devkota,Tiffiney Hartman,Luca Brunelli,Kristen P. Fishler,Omar Abdul-Rahman,Joshua C. Euteneuer, Denise Hoover,
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#Papers: 77
#Citation: 5334
H-Index: 35
G-Index: 73
Sociability: 7
Diversity: 0
Activity: 0
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