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Bio
Research Summary
Nature has evolved sophisticated and highly efficient molecular machineries for all forms of lives. Our lab focuses on engineering DNA-nanostructure-based molecular tools for investigating and engineering the naturally occurring molecular events. Those DNA-based tools have made it possible for us to manipulate macromolecules and higher order assemblies with nanometer precision. We expect such research to help elucidate biological questions at the single-molecule level, and in the long run lead to functional synthetic nano-machines that rival natural systems in complexity.
Research themes in our lab include:
Structural DNA Nanotechnology: rational design of self-assembled DNA nanostructure with ever-increasing complexity and size.
Single-Molecule Biophysics: study of biomolecule interactions through DNA-directed self-assembly and other single-molecule techniques.
Biosensing and Imaging: developing nucleic-acid-based barcodes as multiplexed biosensors and/or in situ imaging probes.
Synthetic Biology: rebuild naturally existing machineries (e.g., SNARE complex, nuclear pore, etc.) with artificial components and/or spatial arrangement.
Research Interests
Biophysics; Cell Membrane; Cell Biology; DNA; Lipid Bilayers; Membrane Fusion; Membranes, Artificial; Reference Standards; Nucleic Acid Probes; Biosensing Techniques; Nuclear Pore; Nanotechnology; Nanostructures
Nature has evolved sophisticated and highly efficient molecular machineries for all forms of lives. Our lab focuses on engineering DNA-nanostructure-based molecular tools for investigating and engineering the naturally occurring molecular events. Those DNA-based tools have made it possible for us to manipulate macromolecules and higher order assemblies with nanometer precision. We expect such research to help elucidate biological questions at the single-molecule level, and in the long run lead to functional synthetic nano-machines that rival natural systems in complexity.
Research themes in our lab include:
Structural DNA Nanotechnology: rational design of self-assembled DNA nanostructure with ever-increasing complexity and size.
Single-Molecule Biophysics: study of biomolecule interactions through DNA-directed self-assembly and other single-molecule techniques.
Biosensing and Imaging: developing nucleic-acid-based barcodes as multiplexed biosensors and/or in situ imaging probes.
Synthetic Biology: rebuild naturally existing machineries (e.g., SNARE complex, nuclear pore, etc.) with artificial components and/or spatial arrangement.
Research Interests
Biophysics; Cell Membrane; Cell Biology; DNA; Lipid Bilayers; Membrane Fusion; Membranes, Artificial; Reference Standards; Nucleic Acid Probes; Biosensing Techniques; Nuclear Pore; Nanotechnology; Nanostructures
Research Interests
Papers共 78 篇Author StatisticsCo-AuthorSimilar Experts
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Qingzhou Feng, Martin Saladin,Chunxiang Wu, Eason Cao,Wei Zheng, Amy Zhang, Pushpanjali Bhardwaj,Xia Li,Qi Shen,Larisa E Kapinos,Malaiyalam Mariappan,C Patrick Lusk,
bioRxiv : the preprint server for biology (2024)
Current Opinion in Cell Biology (2024): 102377-102377
Chemical reviewsno. 7 (2023): 3976-4050
Wangxi Luo,Vladimir Demidov,Qi Shen,Hugo Girão,Manas Chakraborty,Aleksandr Maiorov, Fazly I Ataullakhanov,Chenxiang Lin,Helder Maiato,Ekaterina L Grishchuk
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