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In 2008, we found T cell antigen receptor (TCR) phosphorylation is regulated via the dynamic interaction between TCR intracellular tyrosine motifs and plasma membrane (Xu et al, 2008). This work unveils the presence of an unexpected plasma membrane regulation to immunoreceptor activation other than the well-studied kinase-phosphatase regulation. In addition to study immunoreceptor activation mechanism, we are currently utilizing functional and structural approaches to identify and characterize new signaling proteins involved in immunoreceptor signaling and their roles in human cancers. These studies will advance our knowledge about T cell signaling as well as identify potential drug targets for treating human cancers.
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Papers共 97 篇Author StatisticsCo-AuthorSimilar Experts
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National Science Open (2024)
Cell Chemical Biologyno. 5 (2024): 920-931.e6
EMBO Molecular Medicineno. 2 (2024): 334-360
Life Metabolismno. 5 (2023)
Hui Chen,Xinyi Xu,Wei Hu,Songfang Wu, Jianhui Xiao,Peng Wu, Xiaowen Wang,Xuling Han,Yanruo Zhang,Yong Zhang,Ning Jiang,Wanli Liu,
Proceedings of the National Academy of Sciences of the United States of Americano. 28 (2023)
Jian Chen,Shizhen Qiu, Wentao Li,Kun Wang,Yu Zhang,Han Yang, Baichuan Liu,Guangfei Li, Li Li,Min Chen, Junjie Lan,Jiahua Niu,
Cell Researchno. 5 (2023): 341-354
Journal of medical virologyno. 2 (2023)
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