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The brain, which represents 2% of the body mass but consumes 20% of the body energy at rest, is therefore highly dependent on oxygen and nutrients supply from the blood stream. Key to the functional interdependence between neural and vascular systems is an extraordinarily tight physical association between neurons and endothelial cells, with nearly every neuron in the human brain estimated to be supplied by its own capillary. In addition, normal brain function requires a tightly controlled environment free of toxins and pathogens and with proper chemical compositions for synaptic transmission. The general goal of our research is to understand the mechanisms of how neural and vascular systems coordinately develop, communicate, and work in concert to ensure proper brain function.
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论文共 66 篇作者统计合作学者相似作者
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Alyssa Larios,Chenghua Gu
PHYSIOLOGYno. S1 (2023)
Trevor Krolak,Luke Kaplan, Lujing Chen, Kathleen Navas, Austin Birmingham, Daniel Ryvkin, Victoria Izsa,Chenghua Gu
PHYSIOLOGYno. S1 (2023)
Costantino Iadecola,Eric E Smith,Josef Anrather,Chenghua Gu,Anusha Mishra, Sanjay Misra,Miguel A Perez-Pinzon,Andy Y Shih,Farzaneh A Sorond,Susanne J van Veluw,Cheryl L Wellington, American Heart Association Stroke Council Council on Arteriosclerosis Thrombosis and Vascular Biology Council on Cardiovascular Radiology and Intervention Council on Hypertension Council on Lifestyle and Cardiometabolic Health
Strokeno. 6 (2023): e251-e271
Developmental cellno. 17 (2023): 1534-+
Neuronno. 10 (2022): 1641-1655.e6
Trevor Krolak,Ken Y. Chan,Luke Kaplan, Qin Huang,Jason Wu,Velina Kozareva,Thomas Beddow,Qingxia Zheng,Isabelle G. Tobey,Albert T. Chen,Yujia A. Chan, Daniel Ryvkin,
MOLECULAR THERAPYno. 4 (2022): 244-244
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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