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Description of Research Expertise
Research area:
The pathogenesis of cancer involves not only intrinsic genetic alterations in tumor cells but also the failure of immune surveillance and unresolved inflammation. However, it is not well understood how host-intrinsic or environmental factors direct the immune response towards tumor-promoting inflammation versus anti-tumor immunity during tumor progression. In particular, mucosal surfaces exposed to the external environment are colonized by a vast number of microbes, collectively referred to as the commensal microbiota. Our work and the work of others have just begun to unveil the critical role of commensal microbiome in shaping the tumor microenvironment (TME) at the mucosal sites to regulate the tumor-immune interactions. This is as an area of tremendous opportunity for significant breakthroughs in cancer research.
Research area:
The pathogenesis of cancer involves not only intrinsic genetic alterations in tumor cells but also the failure of immune surveillance and unresolved inflammation. However, it is not well understood how host-intrinsic or environmental factors direct the immune response towards tumor-promoting inflammation versus anti-tumor immunity during tumor progression. In particular, mucosal surfaces exposed to the external environment are colonized by a vast number of microbes, collectively referred to as the commensal microbiota. Our work and the work of others have just begun to unveil the critical role of commensal microbiome in shaping the tumor microenvironment (TME) at the mucosal sites to regulate the tumor-immune interactions. This is as an area of tremendous opportunity for significant breakthroughs in cancer research.
Research Interests
Papers共 45 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jyh Liang Hor, Edward C Schrom, Abigail Wong-Rolle, Luke Vistain, Wanjing Shang, Qiang Dong,Chen Zhao,Chengcheng Jin,Ronald N Germain
biorxiv(2024)
ONCOLOGYno. 7 (2020): 468-477
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Author Statistics
#Papers: 45
#Citation: 8011
H-Index: 23
G-Index: 33
Sociability: 5
Diversity: 3
Activity: 20
Co-Author
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