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Bio
Research Focus:
Molecular Biology of Prions
The principal component of the transmissible agent of spongiform encephalopathies, the prion, is believed to be a conformational variant of the ubiquitous host protein PrPC, and the different properties of various prion strains are attributed to distinct abnormal conformations of this protein. The precise structure of the prion is not known, nor are the mechanisms of infection, conformational conversion and pathogenesis understood.
Many aspects of prion diseases must be studied in animal models, but because they take many months to develop, the molecular processes underlying the replication and spread of prions are best investigated in cell culture. We have isolated cell lines that are extremely sensitive to prion infection and have established an in vitro prion assay that is more sensitive than the traditional mouse bioassay and ten times faster. Using this assay we are trying to generate prion infectivity in vitro, from non-infectious components. We are studying the mechanism by which prions infect cells, the prerequisites for susceptibility to infection and the mechanism by which infectious particles are released by cells.
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Papers共 203 篇Author StatisticsCo-AuthorSimilar Experts
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mag(2014)
Cited22Views0Bibtex
22
0
Alex J Raebera, Fabio Montrasioa, Ivan Hegyia, Rico Frigga, Michael A Kleina,Adriano Aguzzi A,Charles Weissmann B
mag(2013)
Cited23Views0Bibtex
23
0
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