Charles Lawrence

With collaborators we developed a series of models to infer the ages of marine sediments using HMMs and profile HMMs. More recently we developed a Gaussian process (GP) regression models to infer paleo sea surface temperatures (SST) and GP state space models to to align marine sediments. Previously we developed an HMM model to infer events in the regulation of gene expression, and a probabilistic sampling algorithm to infer the Boltzmann ensemble of RNA secondary structures.