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个人简介
Dr. Charles G. Drake is a physician-scientist with a Ph.D. in immunology, whose work focuses on understanding and fighting advanced-stage cancers with the immune system. He is known for rapidly incorporating discoveries made in the research lab into innovative clinical trials, including anti-tumor vaccines.
The Drake laboratory was the first group to show that LymphocyteActivation Gene–3 (LAG-3) is a cell surface marker for CD4 cells with regulatory function (Treg) and that blockade of LAG-3 with a monoclonal antibody could restore anti-tumor immune responses by mitigating CD8 T-cell tolerance in vivo. Further work demonstrated that LAG-3 and PD-1 were co-expressed on functionally exhausted CD8 T cells, suggesting that blockade of multiple immune checkpoints might be required to restore anti-tumor immunity. These discoveries were then translated into clinical trials.
His most recent work has focused on the body’s immunological response to radiation therapy and how immunotherapy and radiation therapy can be used in concert to treat cancer. His research has been published in prestigious journals such as the New England Journal of Medicine, Cancer Research, the Journal of Clinical Investigation, and the Journal of Clinical Oncology.
The Drake laboratory was the first group to show that LymphocyteActivation Gene–3 (LAG-3) is a cell surface marker for CD4 cells with regulatory function (Treg) and that blockade of LAG-3 with a monoclonal antibody could restore anti-tumor immune responses by mitigating CD8 T-cell tolerance in vivo. Further work demonstrated that LAG-3 and PD-1 were co-expressed on functionally exhausted CD8 T cells, suggesting that blockade of multiple immune checkpoints might be required to restore anti-tumor immunity. These discoveries were then translated into clinical trials.
His most recent work has focused on the body’s immunological response to radiation therapy and how immunotherapy and radiation therapy can be used in concert to treat cancer. His research has been published in prestigious journals such as the New England Journal of Medicine, Cancer Research, the Journal of Clinical Investigation, and the Journal of Clinical Oncology.
研究兴趣
论文共 634 篇作者统计合作学者相似作者
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Hannah E. Bergom,Laura A. Sena,Abderrahman Day, Benjamin Miller, Carly D. Miller,John R. Lozada,Nicholas Zorko,Jinhua Wang,Eugene Shenderov,Francisco Pereira Lobo, Fernanda Caramella-Pereira,Luigi Marchionni,
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JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): e17089-e17089
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Patrick J. McCann, Wendy Mao, Matthew Chaimowitz,Erika Houthys, Reece Marillier, Shruti Bansal, Julia An, Jason A. Piersaint, Namita Sen,Charles G. Drake,Catherine S. Spina
CANCER RESEARCHno. 11 (2023)
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Satoshi Wada,Kiyoshi Yoshimura, Edward L. Hipkiss, Tim J. Harris,Hung-Rong Yen,Monica V. Goldberg,Joseph F. Grosso,Derese Getnet,Angelo M. Demarzo, George J. Netto,Robert Anders,Drew M. Pardoll,
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