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个人简介
My research investigates the roles of the extracellular Ca2+, gama-aminobutyric acid (GABA), insulin-like growth factor-1 (IGF1), parathyroid hormone (PTH), FGF23, and vitamin D, and their respective receptors (CaSR, GABBR1, IGF1R, PTH1R, Klotho, and VDR) in (1) controlling mineral homeostasis; (2) mediating skeletal development and facture healing; (3) regulating neuroendocrine functions; and (4) neuroprotection. We study mice with conditional knockout (KO) of genes encoding CaSR, GABBR1, IGF1, IGF1R, PTH1R, Cyp27b1, FGF23, Klotho, VDR, and their associated signaling molecules in parathyroid cells (PTC), intestinal epithelial cells, renal tubule cells, chondrocytes, bone cells, and/or neurons to determine their biological functions. These in vivo studies are complemented with in vitro cell/organ cultures of parathyroid cells/glands; primary intestinal and renal tubular cells and associated cell lines; primary chondrocyte, osteoblast, osteoclast, and related cell lines; and neurons to further delineate the underlying mechanisms. We perform union and nonunion bone fractures on the above KO mice and study the structural, biochemical, and biomechanics properties of the resulting callus to determine the functions of the CaSR, GABBR1, IGF1, IGF1R, PTH1R, Cyp27b1, VDR, and their associated signaling molecules in fracture healing. Based on the above study, we are developing new pharmacological regimens for more robust skeletal anabolism to treat osteoporosis and to repair bone. We also perform brain ischemia and traumatic brain injury protocols on the KO mice to assess the role of those molecules in the development of neuronal injury and to develop new therapies for neuroprotection against ischemia- and TBI-induced brain injury.
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论文共 148 篇作者统计合作学者相似作者
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Fangyu Liu,Cheng-Guo Wu,Chia-Ling Tu, Isabella Glenn,Justin Meyerowitz, Anat Levit Kaplan,Jiankun Lyu,Zhiqiang Cheng, Olga O. Tarkhanova,Yurii S. Moroz,John J. Irwin,Wenhan Chang,
biorxiv(2024)
Prostaglandins, Leukotrienes and Essential Fatty Acidspp.102617, (2024)
Lie-Qi Tang, Johnathan Fraebel, Shi Jin,Steven P Winesett, Jane Harrell,Wen-Han Chang,Sam Xianjun Cheng
World journal of gastroenterologyno. 3 (2024): 268-279
ASPET 2024 Annual Meeting Abstract - Cellular and Molecular Pharmacology (2024)
Fangyu Liu,Cheng-Guo Wu,Chia-Ling Tu, Isabella Glenn,Justin Meyerowitz, Anat Levit Kaplan,Jiankun Lyu,Zhiqiang Cheng, Olga O Tarkhanova,Yurii S Moroz,John J Irwin,Wenhan Chang,
bioRxiv : the preprint server for biology (2024)
Gowoon Son,Mihovil Mladinov, Felipe Pereira,Song Hua Li,Chia-Ling Tu, Grace Judge, Yumi Yang,Claudia Suemoto,Renata Leite, Vitor Paes,Carlos Pasqualucci,Wilson Jacob-Filho,
biorxiv(2024)
Lie-Qi Tang, Johnathan Fraebel, Shi Jin,Steven P. Winesett, Jane Harrell,Wen-Han Chang,Sam Xianjun Cheng
WORLD JOURNAL OF GASTROENTEROLOGYno. 3 (2024)
Guillaume Courbon,Dominik Kentrup,Jane Joy Thomas,Xueyan Wang,Hao-Hsuan Tsai,Jadeah Spindler, John Von Drasek, Laura Mazudie Ndjonko,Marta Martinez-Calle, Sana Lynch, Lauriane Hivert,Xiaofang Wang,
JCI INSIGHTno. 24 (2023)
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