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个人简介
We are interested in lipid metabolism and how it promotes atherosclerosis in the setting of obesity, insulin resistance and diabetes. Our work is translational, spanning cultured cells, animal models and humans.
Fats are partitioned to tissues in highly regulated ways. Excess lipids directed to adipose tissue are stored and lead to obesity, a disorder associated with diabetes, insulin resistance, and heart disease. We engineered mice with ectopic and inducible expression of uncoupling protein-1 (UCP-1) in specific tissues. UCP-1 is an inner mitochondrial anion transporter that uncouples respiration and oxidative phosphorylation. These animals are being used to study the role of metabolism in age-related diseases such as atherosclerosis and hypertension.
Fats are partitioned to tissues in highly regulated ways. Excess lipids directed to adipose tissue are stored and lead to obesity, a disorder associated with diabetes, insulin resistance, and heart disease. We engineered mice with ectopic and inducible expression of uncoupling protein-1 (UCP-1) in specific tissues. UCP-1 is an inner mitochondrial anion transporter that uncouples respiration and oxidative phosphorylation. These animals are being used to study the role of metabolism in age-related diseases such as atherosclerosis and hypertension.
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论文共 291 篇作者统计合作学者相似作者
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Silvia Gonzalez-Nieves,Xiaochao Wei, Jay McQuillan,Qiang Zhang,Jinsong Zhang,Reagan M. McGuffee,David A. Ford,Latisha Love-Gregory,Nada A. Abumrad, Andrew E Gelman,Clay F. Semenkovich,Vincenza Cifarelli
crossref(2024)
Dongliang Lu,Anyuan He,Min Tan, Marguerite Mrad,Amal El Daibani,Donghua Hu, Xuejing Liu,Brian Kleiboeker,Tao Che,Fong-Fu Hsu,Monika Bambouskova,Clay F Semenkovich,
Nature communicationsno. 1 (2024): 4214-4214
Samantha E. Adamson,Sangeeta Adak,Max C. Petersen, Dustin Higgins,Larry D. Spears, Rong Mei Zhang, Andrea Cedeno,Alexis Mckee, Aswathi Kumar, Sudhir Singh,Fong-Fu Hsu,Janet B. Mcgill,
JOURNAL OF LIPID RESEARCHno. 3 (2024): 100519-100519
American journal of physiology. Cell physiologyno. 4 (2024): C1034-C1041
Nature communicationsno. 1 (2024): 45-45
Soma Ghosh, Saumya Bandyopadhyay,Danielle M. Smith,Sangeeta Adak,Clay F. Semenkovich, Laszlo Nagy,Michael J. Wolfgang,Tamara J. O'Connor
PLOS PATHOGENSno. 2 (2024): e1011996-e1011996
Research Square (Research Square) (2023)
Rodrigo Meade,Yang Chao,Nikolai Harroun, Chenglong Li, Shahab Hafezi,Fong-Fu Hsu,Clay F. Semenkovich,Mohamed A. Zayed
JVS - Vascular Science (2023): 100181-100181
The American journal of pathologyno. 12 (2023): 2144-2155
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