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个人简介
Our group seeks to answer the following fundamental questions: How are the final architectures of tissues and organs determined? Specifically, how do individual cells -- the building blocks of these materials -- integrate complex biological signals (both biochemical and mechanical) dynamically and spatially within tissues to direct the development of organs?
The answers to these questions have broad ramifications, from understanding the fundamental mechanisms of development, to delineating the developmental control processes that are circumvented by cancer and other diseases, to elucidating new paradigms required for successful therapeutic approaches in regenerative medicine and tissue engineering. Because of the complexity of the interacting pathways and three-dimensional (3D) nature of developing tissues, this problem requires an interdisciplinary approach, combining expertise from the cell biology, developmental biology, and engineering communities. Our group works at the interface of these disciplines, developing tools to engineer organotypic culture models that mimic tissue development, enabling rigorous quantitative analysis and computational predictions of the dynamics of morphogenesis. Our current focus is on sophisticated mammalian cell culture and mouse models of normal branching morphogenesis (ie, the developmental pr ocess that builds the lung, kidney, and mammary gland) and abnormal neoplastic growth.
The answers to these questions have broad ramifications, from understanding the fundamental mechanisms of development, to delineating the developmental control processes that are circumvented by cancer and other diseases, to elucidating new paradigms required for successful therapeutic approaches in regenerative medicine and tissue engineering. Because of the complexity of the interacting pathways and three-dimensional (3D) nature of developing tissues, this problem requires an interdisciplinary approach, combining expertise from the cell biology, developmental biology, and engineering communities. Our group works at the interface of these disciplines, developing tools to engineer organotypic culture models that mimic tissue development, enabling rigorous quantitative analysis and computational predictions of the dynamics of morphogenesis. Our current focus is on sophisticated mammalian cell culture and mouse models of normal branching morphogenesis (ie, the developmental pr ocess that builds the lung, kidney, and mammary gland) and abnormal neoplastic growth.
研究兴趣
论文共 475 篇作者统计合作学者相似作者
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Cellular and Molecular Bioengineeringno. 1 (2024): 7-24
Current topics in developmental biology (2024): 65-86
Methods in molecular biology (Clifton, N.J.) (2024): 113-124
Developmental Cellno. 10 (2024): 1302-1316.e5
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作者统计
#Papers: 474
#Citation: 23900
H-Index: 66
G-Index: 153
Sociability: 7
Diversity: 0
Activity: 2
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