Research Interests Research interests in my lab are focused on investigating the developmental and genetic etiology of congenital heart disease. These studies use systems approach with large scale forward genetic analysis in mice combined with next generation sequencing in mice and patients to elucidate the genetic etiology of congenital heart disease. Using noninvasive fetal echocardiography, we have conducted a large scale screen of nearly 100,000 fetal mice and identified over 100 genes causing congenital heart disease. Our findings in the mouse models have helped to inform the genes and developmental pathways that can contribute to human congenital heart disease. Our studies have led to the discovery of an important role for the cilium and the endocytic/vesicular trafficking in cardiovascular development and congenital heart disease.