Catherine O'Brien

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Bio

The focus of Dr O’Brien’s lab is to identify the molecular pathways responsible for driving tumour growth in colorectal cancer.

The ultimate goal being to utilize this knowledge to devise improved therapeutic strategies for colorectal cancer.

Research Interests

Papers共 76 篇Author StatisticsCo-AuthorSimilar Experts

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Chronic Viral Mimicry Induction Following P53 Loss Promotes Immune Evasion

Charles A Ishak,Sajid A Marhon,Naïri Tchrakian,Anjelica Hodgson,Helen Loo Yau,Isabela M Gonzaga, Melanie Peralta,Ilinca M Lungu,Stephanie Gomez,Sheng-Ben Liang, Shu Yi Shen,Raymond Chen,Jocelyn Chen, Biji Chatterjee, Kevin N Wanniarachchi,Junwoo Lee, Nicholas Zehrbach,Amir Hosseini,Parinaz Mehdipour,Siyu Sun,Alexander Solovyov,Ilias Ettayebi, Kyle E Francis, Aobo He, Taiyi Wu,Shengrui Feng,Tiago da Silva Medina,Felipe Campos de Almeida,Jane Bayani,Jason Li, Spencer MacDonald, Yadong Wang, Sarah S Garcia,Elisa Arthofer,Noor Diab,Aneil Srivastava,Paul Tran Austin,Peter J B Sabatini,Benjamin D Greenbaum,Catherine A O'Brien, Trevor G Shepherd,Ming Sound Tsao,Katherine B Chiappinelli,Amit M Oza,Blaise A Clarke,Robert Rottapel,Stephanie Lheureux,Daniel D De Carvalho

Cancer discoveryno. 4 (2025): 793-817

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In Vivo CRISPR Screens Identify a Dual Function of MEN1 in Regulating Tumor–microenvironment Interactions

Peiran Su,Yin Liu, Tianyi Chen, Yibo Xue,Yong Zeng,Guanghui Zhu,Sujun Chen,Mona Teng,Xinpei Ci,Mengdi Guo,Michael Y. He,Jun Hao, Vivian Chu,Wenxi Xu,Shiyan Wang,Parinaz Mehdipour,Xin Xu,Sajid A. Marhon,Fraser Soares,Nhu-An Pham, Bell Xi Wu, Peter Hyunwuk Her,Shengrui Feng,Najd Alshamlan, Maryam Khalil,Rehna Krishnan,Fangyou Yu,Chang Chen,Francis Burrows,Razqallah Hakem,Mathieu Lupien,Shane Harding,Benjamin H. Lok,Catherine O'Brien,Alejandro Berlin,Daniel D. De Carvalho,David G. Brooks,Daniel Schramek,Ming-Sound Tsao,Housheng Hansen He

NATURE GENETICS (2024)

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Acute Myeloid Leukemia Drug Tolerant Persister Cells Survive Chemotherapy by Transiently Increasing Plasma Membrane Rigidity, That Also Increases Their Sensitivity to Immune Cell Killing

Yael Morgenstern,JongBok Lee,Yoosu Na, Brandon Y Lieng, Nicholas S Ly,William D Gwynne,Rose Hurren, Li Ma, Dakai Ling,Marcela Gronda,Andrea Arruda,Avraham Frisch,Tsila Zuckerman,Yishai Ofran,Mark D Minden,Li Zhang,Catherine O'Brien,Andrew T Quaile,J Rafael Montenegro-Burke,Aaron D Schimmer

Haematologicano. 4 (2024): 893-903

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18F-Fluoroazomycin Arabinoside (FAZA) PET/MR As a Biomarker of Hypoxia in Rectal Cancer: A Pilot Study

Ur Metser,Andres Kohan,Catherine O'Brien,Rebecca K. S. Wong,Claudia Ortega,Patrick Veit-Haibach,Brandon Driscoll,Ivan Yeung,Adam Farag

TOMOGRAPHY（2024）

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Tables S2-S5 from Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer

Jennifer Haynes,Trevor D. McKee,Andrew Haller,Yadong Wang,Cherry Leung,Deena M.A. Gendoo,Evelyne Lima-Fernandes,Antonija Kreso,Robin Wolman,Eva Szentgyorgyi,Douglass C. Vines,Benjamin Haibe-Kains,Bradly G. Wouters,Ur Metser,David A. Jaffray,Myles Smith,Catherine A. O'Brien

openalex（2023）

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Figure S1-S6 from Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer

openalex（2023）

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AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy by Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing

Yael Morgenstern,JongBok Lee,Yoosu Na,William Gwynne,Rose Hurren, Li Ma,Marcela Gronda,Chaitra Sarathy, Arvind Mer,Andrea Arruda,Avraham Frisch,Tsila Zuckerman,Yishai Ofran,Mark D. Minden,Li Zhang,Catherine O'Brien,J. Rafael Montenegro-Burke,Aaron D. Schimmer

BLOOD (2023)

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Supplementary Data from Prostate Cancer–Associated Gene Expression Alterations Determined from Needle Biopsies

David Z. Qian,Chung-Ying Huang,Catherine A. O'Brien,Ilsa M. Coleman,Mark Garzotto,Lawrence D. True,Celestia S. Higano, Robert Vessella,Paul H. Lange,Peter S. Nelson,Tomasz M. Beer

openalex（2023）

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Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer

Jennifer Haynes,Trevor D. McKee,Andrew Haller,Yadong Wang,Cherry Leung,Deena M. A. Gendoo,Evelyne Lima-Fernandes,Antonija Kreso,Robin Wolman,Eva Szentgyorgyi,Douglass C. Vines,Benjamin Haibe-Kains,Bradly G. Wouters,Ur Metser,David A. Jaffray,Myles Smith,Catherine A. O'Brien

pubmed（2023）

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Associate Professor

Papers共 76 篇Author StatisticsCo-AuthorSimilar Experts