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个人简介
My laboratory studies the neurobiological mechanisms through which early environmental experiences are encoded and maintained into adulthood to have long-lasting impact on behavior. In particular, we are interested in understanding how early life stress increases risk for depression, addiction, and other psychiatric syndromes. This research is translationally motivated by the robust clinical finding that child maltreatment and other forms of early life stress increase the lifetime risk of depression and other mood, anxiety, and drug disorders by 2-4 -fold. Studies in humans and animals suggest that early life stress sensitizes individuals to exposures such as stress encountered later in life. To understand the neurobiological mechanisms underlying this latent behavioral vulnerability, we are integrating a range of technical approaches including rodent behavior, RNA and chromatin sequencing and bioinformatic analysis, in vivo cell-specific gene manipulation, and high-resolution imaging. By understanding how early life stress affects brain development at multiple levels - epigenetic and molecular, neuroendocrine, cells and circuits - we ultimately hope to apply such knowledge towards innovative therapies relevant to individuals who experienced childhood stress and trauma.
研究兴趣
论文共 64 篇作者统计合作学者相似作者
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HORMONES AND BEHAVIOR (2024): 105472-105472
Rebekah L Rashford, Michael DeBerardine, Hye Ji J Kim, Nibal Arzouni, Laura W Hirschfield, Oluwamayowa M Oke,Shannon N Bennett,Catherine Jensen Pena
crossref(2024)
Hormones and behavior (2023): 105364-105364
Nature Neuroscienceno. 7 (2023): 1229-1244
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Sero Toriano Parel,Shannon N Bennett, Cindy J Cheng, Olivia C Timmermans,Laura M Fiori,Gustavo Turecki,Catherine Jensen Peña
Proceedings of the National Academy of Sciences of the United States of Americano. 49 (2023)
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JOURNAL OF NEUROSCIENCEno. 34 (2023): 5996-6009
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv : the preprint server for biologyno. 22 (2023): 3541-3553.e8
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Kerri D Pryce,Aarthi Ramakrishnan, Hope Kronnman,Andrew Nicolais,Claire Polizu,Anne Ruiz,Randal Serafini,Sevasti Gaspari,Catherine J Pena,Angelica Torres-Berrio, Vassiliki Mitsi, Matthew Darpe,
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