基本信息
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职业迁徙
个人简介
Research Interests
Cell Signaling; Myelin; Regeneration
Myelin is a protective coating that ensheathes the nerve fibers (termed axons) which carry information to and from the brain. Its main purpose is to enhance the speed of impulse conduction and to protect axons from unnecessary damage. Myelin can be impaired from traumatic injury or also from diseases like multiple sclerosis and leukodystrophy. In such cases, loss of myelin can lead to paralysis, loss of sensation, of learning impairments; however, work is being done to understand how myelin can be regenerated (a process termed re-myelination) which may help alleviate these negative outcomes.
Dr. Catherine Pallen is highly regarded for her research on cell signaling and understanding the role and mechanism by which a molecule called PTPa (protein tyrosine phosphatase alpha) influences myelination. Her work has shown that PTPa is required for normal growth and maturation of myelin-producing cells and she has developed experimental models to investigate how PTPa functions for myelin repair.
Cell Signaling; Myelin; Regeneration
Myelin is a protective coating that ensheathes the nerve fibers (termed axons) which carry information to and from the brain. Its main purpose is to enhance the speed of impulse conduction and to protect axons from unnecessary damage. Myelin can be impaired from traumatic injury or also from diseases like multiple sclerosis and leukodystrophy. In such cases, loss of myelin can lead to paralysis, loss of sensation, of learning impairments; however, work is being done to understand how myelin can be regenerated (a process termed re-myelination) which may help alleviate these negative outcomes.
Dr. Catherine Pallen is highly regarded for her research on cell signaling and understanding the role and mechanism by which a molecule called PTPa (protein tyrosine phosphatase alpha) influences myelination. Her work has shown that PTPa is required for normal growth and maturation of myelin-producing cells and she has developed experimental models to investigate how PTPa functions for myelin repair.
研究兴趣
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crossref(2023)
crossref(2023)
Abbas Fotovati,Samah Abu-Ali,Pei-Shan Wang,Loic P. Deleyrolle,Cathy Lee,Joanna Triscott,James Y. Chen,Sonia Franciosi, Yasuhiro Nakamura,Yasuo Sugita,Takeshi Uchiumi, Michihiko Kuwano,
crossref(2023)
CLINICAL & EXPERIMENTAL METASTASISno. 2 (2019): 156.0-157.0
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Cameron A. Rogers,Catherine J. Pallen
Protein Tyrosine Phosphatases in Cancerpp.261-282, (2016)
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