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个人简介
Her research centers on development and application of MS-based methods to study glycobiology, protein post-translational modifications and folding disorders, cardiovascular and infectious diseases, and bioactive lipids. Major current development projects include Mass Spectrometry Imaging using Matrix-Assisted laser Desorption/Ionization, with emphasis on its application to Chronic Traumatic Encephalopathy (CTE) and Traumatic Brain Injury (TBI); Ion Mobility Coupled to Mass Spectrometry, particularly for the characterization of glycans, glycoconjugates and protein complexes; and exploration of the fragmentation pathways for glycans and glycoconjugates initiated by Electron-based Dissociation methods (ExD). Current collaborative studies include glycan mapping and structural determinations in cancer, signalling, infectious diseases and archaea, protein post-translational modifications that are evidence of oxidative stress, investigations of HLA-DR antigen presentation in Lyme Disease and Rheumatoid Arthritis, MS-based studies of CTE and TBI, the adaptation of ExD to Ion Mobility MS, applications of Ion Mobility and cross-linking to understanding protein misfolding in systemic amyloid and prion diseases, and RNA binding proteins of Trypanosomes.
研究兴趣
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