The group, now led by Dr Matthew Hurles, has research interests in chromosome rearrangement, chromosome organisation, karyotype evolution and DNA homology between species. Underpinning much of this research has been the development of array-CGH. This technology has been used for various studies in the group including the identification of copy number variation in human populations and the detection of genomic gains and losses in single cells. Using ultra-high resolution oligonucleotide arrays and flow sorting of derivative chromosomes the group have further developed the method of array painting to facilitate the mapping and sequencing balanced translocation breakpoints efficiently and rapidly.