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Bio
I am a multidisciplinary researcher with 15 years of experience in the neuroscience field (H-index 19, Google Scholar). My research focuses on the use of "disease-in-a-dish" models to study the mechanism underlying neurodegenerative diseases and as tools for drug discovery. In 2008, after finishing my degree in biology with excellent qualifications, I obtained a CIBERER "Lanzadera" fellowship to start my PhD in the laboratory of Dr. Ángeles Martín-Requero (CIB-CSIC, Madrid). My thesis project focused in studying the mechanisms by which progranulin regulates cell proliferation/death in frontotemporal dementia (FTLD). Furthermore, I also participated in other projects studying the molecular mechanism altered in other neurodegenerative diseases such as Alzheimer´s disease and Parkinson’s disease. In 2014, I finalized my PhD with cum-laude qualification and then, I obtained a prestigious postdoctoral Fellowship from the Ramón Areces Foundation that allow me to start my postdoc at Dr. Aimee Kao’s laboratory (UCSF, USA).
In Dr. Kao's laboratory, I studied the mechanisms that contribute to tau accumulation and neurodegeneration, utilizing cutting-edge techniques like CRISPR/Cas9 genome editing, iPSC culture, and neuronal differentiation. After completing my postdoc, I became an Assistant Professional Researcher in the Department of Neurology at UCSF (October 2020 to December 2021). During this time, I studied on the role of the TSC1 protein in regulating tau accumulation and degradation. This ongoing project received funding from the Rainwater Charitable Foundation-Tau Consortium and was developed in collaboration with Dr. Aimee Kao and Dr. David Agard (UCSF). Recently, I received a Miguel Servet Grant (Instituto de Salud Carlos III AES2021, CP21/00049) that allowed me to establish my research group at the Research Institute of the Hospital 12 de Octubre (i+12 Institute) in Madrid, Spain. Here, I am using patient-derived neurons and brain organoids to investigate the molecular mechanisms involved in neurodegenerative diseases.
My research has significantly contributed to the better understanding of the etiology of neurodegenerative diseases, as well as to the development of potential cures as my research have led to the identification of new biomarkers, therapeutic targets, and treatments. To date, I have published 35 papers (16 as lead author) and a book chapter. I am also dedicated to disseminating my research, as evidenced by the 21 works I have presented at both international and national scientific conferences, including posters and talks. My expertise in the field of neurodegeneration has led to several invitations to participate as a speaker at outstanding meetings such as, 2022 Emerging Leaders in Neuroscience, 2020 Challenge Network-Chan Zuckerberg Initiative, Tau Consortium Investigators Meeting 21, 2020 AAT-ADPD meeting, Bay Area Aging Meting (BAAM 2018) or 2022 NEURO-CENL symposium, among others.
Throughout my career, I have participated in several research projects funded by competitive national and international calls, four of which I have led as the principal investigator (CP21/00049, PI22/000345, FERP-2022-5, and XXVIII postdoctoral fellowship Ramon Areces). My current research is multidisciplinary and translational, and my research group is composed for basic researchers as well as clinicians from the 12 de Octubre Hospital in Madrid. Furthermore, I have collaborators from other institutions such as the Clinic Hospital in Barcelona and the Instituto de Investigaciones Biomédicas (iib) in Madrid. Additionally, during my career I have collaborated with other researchers specialized in neurodegeneration from institutions across Spain, Europe, and the US, and have participated in research structures including CIBERER, Tau Consortium, SENC and Women in Autophagy (WIA).
I am strongly commited to mentoring and outreach activities. To date, I have supervised 16 undergraduate and postgraduate students, including three that are currently working on doctoral theses. In addition, I have taught courses at both the University Complutense of Madrid and the University of California, San Francisco. Moreover, am part of the mentoring committee of the i+12 Institute, Women in Astronomy (WIA), Chan Zuckerberg Initiative's Neurodegeneration Challenge Network (CZI-NDCN), Action Potential Advising Program, Camp Talaria, and the "Science in the Schools" program (ECUSA). I am also organizing the first Junior Researchers Meeting of the i+12 Institute. In alignment with my commitment to advancing scientific research, I actively collaborate with specialized neuroscience journals as a reviewer and guest editor and I am currently part of the reviewrs panel of the National Science Centre in Poland.
Research Interests
Papers共 39 篇Author StatisticsCo-AuthorSimilar Experts
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Guiomar Rodriguez-Perinan,Ana de la Encarnacion,Fermin Moreno,Adolfo Lopez de Munain,Ana Martinez,Angeles Martin-Requero,Carolina Alquezar,Fernando Bartolome
Acta neuropathologicano. 1 (2022): 1-12
FRONTIERS IN NEUROLOGY (2021): 595532-595532
bioRxiv (Cold Spring Harbor Laboratory) (2020)
Scientific reportsno. 1 (2020): 569-569
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Author Statistics
#Papers: 38
#Citation: 665
H-Index: 16
G-Index: 25
Sociability: 5
Diversity: 1
Activity: 1
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