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Bio
Carole Linster is an Associate Professor in Biochemistry at the Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, where she is heading the Enzymology & Metabolism Group since 2013. From 2017-2022, she also built up and was responsible for the LCSB Metabolomics Platform, which provides mass spectrometry-based small molecule analyses for research groups in Luxembourg and abroad. Carole Linster studied biomedical sciences at the Medical Faculty of UCLouvain (Brussels, Belgium). After completing her PhD in 2006 at the de Duve Institute, she moved to the United States where she worked as a postdoctoral fellow at the University of California Los Angeles and discovered the enzyme GDP-L-galactose phosphorylase (VTC2), which plants depend on to produce vitamin C. During the period in UCLA and a second postdoctoral stay back in Brussels (de Duve Institute), Carole Linster and co-workers discovered four new metabolite repair enzymes involved in the breakdown of metabolic side products that are constantly formed in our cells. In collaboration with researchers from Australia, the US and the UK, the Linster group recently identified a novel infantile rare neurodegenerative disorder that is caused by the deficiency of one of those metabolite repair enzymes (NAXD). The group also deploys increasing efforts towards disease modeling, in yeast and human cells as well as zebrafish, and drug repurposing for rare diseases. In addition to enzyme function discovery and rare disease research, the Linster group has made important contributions to research on the aging process, with the development of high-throughput aging assays and the identification of new genetic factors that modulate aging in yeast.
Research Interests
Papers共 61 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of Biological Chemistryno. 3 (2024)
Mina Tsenkova, Madita Brauer, Marat Kasakin,Susheel Bhanu Busi,Maryse Schmoetten,Anthoula Gaigneaux,Vitaly Pozdeev,Marianne Meyers,Eric Koncina,Diran Herebian,Fabien Rodriguez, Dean Cheung,
biorxiv(2024)
Journal of Biological Chemistryno. 3 (2024)
Micro and Nano Engineering (2023): 100199-100199
Research Square (Research Square) (2023)
Biomedicinesno. 10 (2023): 2842-2842
Analytical and bioanalytical chemistryno. 17 (2023): 3415-3434
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Author Statistics
#Papers: 61
#Citation: 4116
H-Index: 25
G-Index: 46
Sociability: 6
Diversity: 3
Activity: 10
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